TY - JOUR
T1 - DELLA functions evolved by rewiring of associated transcriptional networks
AU - Briones-Moreno, Asier
AU - Hernández-García, Jorge
AU - Vargas-Chávez, Carlos
AU - Blanco-Touriñán, Noel
AU - Phokas, Alexandros
AU - Úrbez, Cristina
AU - Cerdán, Pablo D.
AU - Coates, Juliet C.
AU - Alabadí, David
AU - Blázquez, Miguel A.
PY - 2023/4
Y1 - 2023/4
N2 - DELLA proteins are land-plant specific transcriptional regulators that transduce environmental information to multiple processes throughout a plant’s life1–3. The molecular basis for this critical function in angiosperms has been linked to the regulation of DELLA stability by gibberellins and to the capacity of DELLA proteins to interact with hundreds of transcription factors4,5. Although bryophyte orthologues can partially fulfil functions attributed to angiosperm DELLA6,7, it is not clear whether the capacity to establish interaction networks is an ancestral property of DELLA proteins or is associated with their role in gibberellin signalling8–10. Here we show that representative DELLAs from the main plant lineages display a conserved ability to interact with multiple transcription factors. We propose that promiscuity was encoded in the ancestral DELLA protein, and that this property has been largely maintained, whereas the lineage-dependent diversification of DELLA-dependent functions mostly reflects the functional evolution of their interacting partners.
AB - DELLA proteins are land-plant specific transcriptional regulators that transduce environmental information to multiple processes throughout a plant’s life1–3. The molecular basis for this critical function in angiosperms has been linked to the regulation of DELLA stability by gibberellins and to the capacity of DELLA proteins to interact with hundreds of transcription factors4,5. Although bryophyte orthologues can partially fulfil functions attributed to angiosperm DELLA6,7, it is not clear whether the capacity to establish interaction networks is an ancestral property of DELLA proteins or is associated with their role in gibberellin signalling8–10. Here we show that representative DELLAs from the main plant lineages display a conserved ability to interact with multiple transcription factors. We propose that promiscuity was encoded in the ancestral DELLA protein, and that this property has been largely maintained, whereas the lineage-dependent diversification of DELLA-dependent functions mostly reflects the functional evolution of their interacting partners.
U2 - 10.1038/s41477-023-01372-6
DO - 10.1038/s41477-023-01372-6
M3 - Article
C2 - 36914897
AN - SCOPUS:85149916187
SN - 2055-026X
VL - 9
SP - 535
EP - 543
JO - Nature Plants
JF - Nature Plants
IS - 4
ER -