DELLA functions evolved by rewiring of associated transcriptional networks

Asier Briones-Moreno, Jorge Hernández-García, Carlos Vargas-Chávez, Noel Blanco-Touriñán, Alexandros Phokas, Cristina Úrbez, Pablo D. Cerdán, Juliet C. Coates, David Alabadí, Miguel A. Blázquez*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

DELLA proteins are land-plant specific transcriptional regulators that transduce environmental information to multiple processes throughout a plant’s life1–3. The molecular basis for this critical function in angiosperms has been linked to the regulation of DELLA stability by gibberellins and to the capacity of DELLA proteins to interact with hundreds of transcription factors4,5. Although bryophyte orthologues can partially fulfil functions attributed to angiosperm DELLA6,7, it is not clear whether the capacity to establish interaction networks is an ancestral property of DELLA proteins or is associated with their role in gibberellin signalling8–10. Here we show that representative DELLAs from the main plant lineages display a conserved ability to interact with multiple transcription factors. We propose that promiscuity was encoded in the ancestral DELLA protein, and that this property has been largely maintained, whereas the lineage-dependent diversification of DELLA-dependent functions mostly reflects the functional evolution of their interacting partners.

Original languageEnglish
Pages (from-to)535-543
JournalNature Plants
Volume9
Issue number4
DOIs
Publication statusPublished - Apr 2023

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