TY - JOUR
T1 - Delivery of genome editing tools by bacterial extracellular vesicles
AU - Liu, Yue
AU - Smid, Eddy J.
AU - Abee, Tjakko
AU - Notebaart, Richard A.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Here we propose to use bacterial cells as factories that generate EVs harboring both the RNP complex (or any other CRISPR‐mediated tool) and a specific ligand molecule. The ligand would allow specific binding of EVs to cells with the matching receptors, adding a level of specificity to the delivery, hence stimulating precise genome editing.
AB - Here we propose to use bacterial cells as factories that generate EVs harboring both the RNP complex (or any other CRISPR‐mediated tool) and a specific ligand molecule. The ligand would allow specific binding of EVs to cells with the matching receptors, adding a level of specificity to the delivery, hence stimulating precise genome editing.
U2 - 10.1111/1751-7915.13356
DO - 10.1111/1751-7915.13356
M3 - Article
C2 - 30549228
AN - SCOPUS:85058663212
SN - 1751-7907
VL - 12
SP - 71
EP - 73
JO - Microbial Biotechnology
JF - Microbial Biotechnology
IS - 1
ER -