Deleterious alleles in the context of domestication, inbreeding, and selection

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Each individual has a certain number of harmful mutations in its genome. These mutations can lower the fitness of the individual carrying them, dependent on their dominance and selection coefficient. Effective population size, selection, and admixture are known to affect the occurrence of such mutations in a population. The relative roles of demography and selection are a key in understanding the process of adaptation. These are factors that are potentially influenced and confounded in domestic animals. Here, we hypothesize that the series of events of bottlenecks, introgression, and strong artificial selection associated with domestication increased mutational load in domestic species. Yet, mutational load is hard to quantify, so there are very few studies available revealing the relevance of evolutionary processes. The precise role of artificial selection, bottlenecks, and introgression in further increasing the load of deleterious variants in animals in breeding and conservation programmes remains unclear. In this paper, we review the effects of domestication and selection on mutational load in domestic species. Moreover, we test some hypotheses on higher mutational load due to domestication and selective sweeps using sequence data from commercial pig and chicken lines. Overall, we argue that domestication by itself is not a prerequisite for genetic erosion, indicating that fitness potential does not need to decline. Rather, mutational load in domestic species can be influenced by many factors, but consistent or strong trends are not yet clear. However, methods emerging from molecular genetics allow discrimination of hypotheses about the determinants of mutational load, such as effective population size, inbreeding, and selection, in domestic systems. These findings make us rethink the effect of our current breeding schemes on fitness of populations.

LanguageEnglish
Pages6-17
JournalEvolutionary Applications
Volume12
Issue number1
Early online date11 Aug 2018
DOIs
Publication statusPublished - 2019

Fingerprint

Inbreeding
domestication
inbreeding
allele
domestic species
Alleles
alleles
artificial selection
Population Density
mutation
introgression
Mutation
Breeding
fitness
population size
effective population size
animal breeding
conservation programs
Domestic Animals
demography

Keywords

  • deleterious alleles
  • domestication
  • genetic load
  • inbreeding
  • selection

Cite this

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title = "Deleterious alleles in the context of domestication, inbreeding, and selection",
abstract = "Each individual has a certain number of harmful mutations in its genome. These mutations can lower the fitness of the individual carrying them, dependent on their dominance and selection coefficient. Effective population size, selection, and admixture are known to affect the occurrence of such mutations in a population. The relative roles of demography and selection are a key in understanding the process of adaptation. These are factors that are potentially influenced and confounded in domestic animals. Here, we hypothesize that the series of events of bottlenecks, introgression, and strong artificial selection associated with domestication increased mutational load in domestic species. Yet, mutational load is hard to quantify, so there are very few studies available revealing the relevance of evolutionary processes. The precise role of artificial selection, bottlenecks, and introgression in further increasing the load of deleterious variants in animals in breeding and conservation programmes remains unclear. In this paper, we review the effects of domestication and selection on mutational load in domestic species. Moreover, we test some hypotheses on higher mutational load due to domestication and selective sweeps using sequence data from commercial pig and chicken lines. Overall, we argue that domestication by itself is not a prerequisite for genetic erosion, indicating that fitness potential does not need to decline. Rather, mutational load in domestic species can be influenced by many factors, but consistent or strong trends are not yet clear. However, methods emerging from molecular genetics allow discrimination of hypotheses about the determinants of mutational load, such as effective population size, inbreeding, and selection, in domestic systems. These findings make us rethink the effect of our current breeding schemes on fitness of populations.",
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Deleterious alleles in the context of domestication, inbreeding, and selection. / Bosse, Mirte; Megens, Hendrik-Jan; Derks, Martijn F.L.; de Cara, Ángeles M.R.; Groenen, Martien A.M.

In: Evolutionary Applications, Vol. 12, No. 1, 2019, p. 6-17.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Deleterious alleles in the context of domestication, inbreeding, and selection

AU - Bosse, Mirte

AU - Megens, Hendrik-Jan

AU - Derks, Martijn F.L.

AU - de Cara, Ángeles M.R.

AU - Groenen, Martien A.M.

PY - 2019

Y1 - 2019

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