Deazaflavins are potentially useful redox mediators for the direct, nicotinamide-independent regeneration of oxidoreductases. Especially the O2-stability of their reduced forms have attracted significant interest for the regeneration of monooxygenases. In this contribution we further investigate the photochemical properties of deazaflavins and investigate the scope and limitations of deazaflavin-based photoenzymatic reaction systems.
- Old yellow enzyme
- Oxygen dilemma
van Schie, M. M. C. H., Younes, S. H. H., Rauch, M. C. R., Pesic, M., Paul, C. E., Arends, I. W. C. E., & Hollmann, F. (2018). Deazaflavins as photocatalysts for the direct reductive regeneration of flavoenzymes. Molecular Catalysis, 452, 277-283. https://doi.org/10.1016/j.mcat.2018.04.015