Dark chocolate consumption improves leukocyte adhesion factors and vascular function in overweight men

D. Esser, M. Mars, E. Oosterink, A. Stalmach, M.R. Müller, L.A. Afman

Research output: Contribution to journalArticleAcademicpeer-review

41 Citations (Scopus)

Abstract

Flavanol-enriched chocolate consumption increases endothelium-dependent vasodilation. Most research so far has focused on flow-mediated dilation (FMD) only; the effects on other factors relevant to endothelial health, such as inflammation and leukocyte adhesion, have hardly been addressed. We investigated whether consumption of regular dark chocolate also affects other markers of endothelial health, and whether chocolate enrichment with flavanols has additional benefits. In a randomized double-blind crossover study, the effects of acute and of 4 wk daily consumption of high flavanol chocolate (HFC) and normal flavanol chocolate (NFC) on FMD, augmentation index (AIX), leukocyte count, plasma cytokines, and leukocyte cell surface molecules in overweight men (age 45–70 yr) were investigated. Sensory profiles and motivation scores to eat chocolate were also collected. Findings showed that a 4 wk chocolate intake increased FMD by 1%, which was paralleled by a decreased AIX of 1%, decreased leukocyte cell count, decreased plasma sICAM1 and sICAM3, and decreased leukocyte adhesion marker expression (P
Original languageEnglish
Pages (from-to)1464-1473
JournalFASEB Journal
Volume28
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • flavanol-rich cocoa
  • endothelial function
  • mediated vasodilatation
  • cardiovascular health
  • postprandial lipemia
  • repeated exposure
  • metaanalysis
  • disease
  • atherosclerosis
  • prediction

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