Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes

E.A. Struijk, A. Heraclides, D.R. Witte, S.S. Soedamah-Muthu, J.M. Geleijnse, U. Toft, C.J. Lau

Research output: Contribution to journalArticleAcademicpeer-review

47 Citations (Scopus)

Abstract

Background and aim A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. Methods and results A total of 5953 Danish men and women aged 30–60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (ß = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (ß = -0.028, 95% CI -0.048; -0.008) and HbA1c (ß = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. Conclusion Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.
LanguageEnglish
Pages822-828
JournalNutrition, Metabolism & Cardiovascular Diseases
Volume23
Issue number9
DOIs
Publication statusPublished - 2013

Fingerprint

Dairy Products
Type 2 Diabetes Mellitus
Glucose
Cheese
Cultured Milk Products
Fasting
Fats
Insulin Resistance
Life Style
Milk
Cardiovascular Diseases
Demography
Incidence

Keywords

  • vitamin-k
  • consumption
  • mellitus
  • women
  • disease
  • men
  • phylloquinone
  • menaquinones
  • metaanalysis
  • association

Cite this

Struijk, E.A. ; Heraclides, A. ; Witte, D.R. ; Soedamah-Muthu, S.S. ; Geleijnse, J.M. ; Toft, U. ; Lau, C.J. / Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. In: Nutrition, Metabolism & Cardiovascular Diseases. 2013 ; Vol. 23, No. 9. pp. 822-828.
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abstract = "Background and aim A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. Methods and results A total of 5953 Danish men and women aged 30–60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG ({\ss} = -0.048, 95{\%} CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG ({\ss} = -0.028, 95{\%} CI -0.048; -0.008) and HbA1c ({\ss} = -0.016, 95{\%} CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. Conclusion Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.",
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Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes. / Struijk, E.A.; Heraclides, A.; Witte, D.R.; Soedamah-Muthu, S.S.; Geleijnse, J.M.; Toft, U.; Lau, C.J.

In: Nutrition, Metabolism & Cardiovascular Diseases, Vol. 23, No. 9, 2013, p. 822-828.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes

AU - Struijk, E.A.

AU - Heraclides, A.

AU - Witte, D.R.

AU - Soedamah-Muthu, S.S.

AU - Geleijnse, J.M.

AU - Toft, U.

AU - Lau, C.J.

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N2 - Background and aim A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. Methods and results A total of 5953 Danish men and women aged 30–60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (ß = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (ß = -0.028, 95% CI -0.048; -0.008) and HbA1c (ß = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. Conclusion Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.

AB - Background and aim A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. Methods and results A total of 5953 Danish men and women aged 30–60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (ß = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (ß = -0.028, 95% CI -0.048; -0.008) and HbA1c (ß = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. Conclusion Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.

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KW - consumption

KW - mellitus

KW - women

KW - disease

KW - men

KW - phylloquinone

KW - menaquinones

KW - metaanalysis

KW - association

U2 - 10.1016/j.numecd.2012.05.011

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JO - Nutrition, Metabolism & Cardiovascular Diseases

T2 - Nutrition, Metabolism & Cardiovascular Diseases

JF - Nutrition, Metabolism & Cardiovascular Diseases

SN - 0939-4753

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