Dairy-inspired coatings for bone implants from whey protein isolate-derived self-assembled fibrils

Rebecca Rabe, Ute Hempel, Laurine Martocq*, Julia K. Keppler, Jenny Aveyard, Timothy E.L. Douglas

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


To improve the integration of a biomaterial with surrounding tissue, its surface properties may be modified by adsorption of biomacromolecules, e.g., fibrils. Whey protein isolate (WPI), a dairy industry by-product, supports osteoblastic cell growth. WPI’s main component, β-lactoglobulin, forms fibrils in acidic solutions. In this study, aiming to develop coatings for biomaterials for bone contact, substrates were coated with WPI fibrils obtained at pH 2 or 3.5. Importantly, WPI fibrils coatings withstood autoclave sterilization and appeared to promote spreading and differentiation of human bone marrow stromal cells (hBMSC). In the future, WPI fibrils coatings could facilitate immobilization of biomolecules with growth stimulating or antimicrobial properties.

Original languageEnglish
Article number5544
JournalInternational Journal of Molecular Sciences
Issue number15
Publication statusPublished - 1 Aug 2020


  • Bone
  • Coating
  • Fibril
  • Stem cell
  • Whey protein isolate

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