Cytokines related to nutritional status in patients with untreated pulmonary tuberculosis in Indonesia

E. Karyadi, W.M.V. Dolmans, C.E. West, R. Crevel, R.H.H. Nelwan, Z. Amin, R. Gross, J. Van der Ven-Jongekrijg, J.W.M. van der Meer

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Abstract

Although several studies have dealt with the patterns of cytokine production in tuberculosis, little is known about the association between nutrient deficiencies and cytokines in tuberculosis. The objective of this study was to assess the concentration of cytokines related to nutritional status during tuberculosis. In 41 untreated tuberculosis patients and matched healthy controls in an urban hospital in Indonesia, we measured: height and weight, parameters of iron, vitamin A and zinc; and cytokines concentrations in the circulation and production in whole blood cultures. Plasma interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1ra) were significantly higher in patients than in controls. Patients with cavities (n=26) had higher concentrations of IL-6 than patients without cavities (n=15). Body mass index
Original languageEnglish
Pages (from-to)218-226
JournalAsia Pacific Journal of Clinical Nutrition
Volume16
Issue number2
Publication statusPublished - 2007

Keywords

  • necrosis-factor-alpha
  • vitamin-a
  • zinc-deficiency
  • mycobacterium-tuberculosis
  • interleukin-6
  • supplementation
  • malnutrition
  • secretion
  • infection
  • children

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    Karyadi, E., Dolmans, W. M. V., West, C. E., Crevel, R., Nelwan, R. H. H., Amin, Z., Gross, R., Van der Ven-Jongekrijg, J., & van der Meer, J. W. M. (2007). Cytokines related to nutritional status in patients with untreated pulmonary tuberculosis in Indonesia. Asia Pacific Journal of Clinical Nutrition, 16(2), 218-226. http://apjcn.nhri.org.tw/server/APJCN/16/2/218.pdf