Cytokines in lethal graft-versus-host disease

A.C. Knulst, C. Bril-Bazuin, G.J.M. Tibbe, A. van Oudenaren, H.F.J. Savelkoul, R. Benner

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Graft-versus-host disease (GVHD) is caused by donor T lymphocytes that recognize foreign antigens on host tissues. This leads to T cell activation, which involves a cascade of events including the transcription of genes for cytokines and their receptors and the production of cytokines. One of the first cytokines to appear is interleukin 2 (IL-2). IL-2 production enhances the IL-2 receptor expression and leads to T cell proliferation. As a further step, differentation of T cells occurs, which results in the production of a certain pattern of cytokines. These cytokines influence the expression of cell surface antigens and adhesion molecules, and are able to activate other cell types such as cytotoxic T cells, macrophages and natural killer cells, which might act as effector cells in tissue destruction. Insight into the sequential expression of the various cytokines involved might enable a more effective treatment of GVHD. Therefore, we investigated the occurrence of cytokines in a murine model for acute GVHD. We addressed in particular the period early after allogeneic reconstitution.
LanguageEnglish
Pages679-680.
JournalTransplant International
Volume5
Publication statusPublished - 1992
Externally publishedYes

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Graft vs Host Disease
Cytokines
T-Lymphocytes
Interleukin-2
Cytokine Receptors
Interleukin-2 Receptors
Surface Antigens
Natural Killer Cells
Macrophages
Cell Proliferation
Antigens
Genes

Cite this

Knulst, A. C., Bril-Bazuin, C., Tibbe, G. J. M., van Oudenaren, A., Savelkoul, H. F. J., & Benner, R. (1992). Cytokines in lethal graft-versus-host disease. Transplant International, 5, 679-680..
Knulst, A.C. ; Bril-Bazuin, C. ; Tibbe, G.J.M. ; van Oudenaren, A. ; Savelkoul, H.F.J. ; Benner, R. / Cytokines in lethal graft-versus-host disease. In: Transplant International. 1992 ; Vol. 5. pp. 679-680.
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abstract = "Graft-versus-host disease (GVHD) is caused by donor T lymphocytes that recognize foreign antigens on host tissues. This leads to T cell activation, which involves a cascade of events including the transcription of genes for cytokines and their receptors and the production of cytokines. One of the first cytokines to appear is interleukin 2 (IL-2). IL-2 production enhances the IL-2 receptor expression and leads to T cell proliferation. As a further step, differentation of T cells occurs, which results in the production of a certain pattern of cytokines. These cytokines influence the expression of cell surface antigens and adhesion molecules, and are able to activate other cell types such as cytotoxic T cells, macrophages and natural killer cells, which might act as effector cells in tissue destruction. Insight into the sequential expression of the various cytokines involved might enable a more effective treatment of GVHD. Therefore, we investigated the occurrence of cytokines in a murine model for acute GVHD. We addressed in particular the period early after allogeneic reconstitution.",
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Knulst, AC, Bril-Bazuin, C, Tibbe, GJM, van Oudenaren, A, Savelkoul, HFJ & Benner, R 1992, 'Cytokines in lethal graft-versus-host disease', Transplant International, vol. 5, pp. 679-680..

Cytokines in lethal graft-versus-host disease. / Knulst, A.C.; Bril-Bazuin, C.; Tibbe, G.J.M.; van Oudenaren, A.; Savelkoul, H.F.J.; Benner, R.

In: Transplant International, Vol. 5, 1992, p. 679-680.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Cytokines in lethal graft-versus-host disease

AU - Knulst, A.C.

AU - Bril-Bazuin, C.

AU - Tibbe, G.J.M.

AU - van Oudenaren, A.

AU - Savelkoul, H.F.J.

AU - Benner, R.

PY - 1992

Y1 - 1992

N2 - Graft-versus-host disease (GVHD) is caused by donor T lymphocytes that recognize foreign antigens on host tissues. This leads to T cell activation, which involves a cascade of events including the transcription of genes for cytokines and their receptors and the production of cytokines. One of the first cytokines to appear is interleukin 2 (IL-2). IL-2 production enhances the IL-2 receptor expression and leads to T cell proliferation. As a further step, differentation of T cells occurs, which results in the production of a certain pattern of cytokines. These cytokines influence the expression of cell surface antigens and adhesion molecules, and are able to activate other cell types such as cytotoxic T cells, macrophages and natural killer cells, which might act as effector cells in tissue destruction. Insight into the sequential expression of the various cytokines involved might enable a more effective treatment of GVHD. Therefore, we investigated the occurrence of cytokines in a murine model for acute GVHD. We addressed in particular the period early after allogeneic reconstitution.

AB - Graft-versus-host disease (GVHD) is caused by donor T lymphocytes that recognize foreign antigens on host tissues. This leads to T cell activation, which involves a cascade of events including the transcription of genes for cytokines and their receptors and the production of cytokines. One of the first cytokines to appear is interleukin 2 (IL-2). IL-2 production enhances the IL-2 receptor expression and leads to T cell proliferation. As a further step, differentation of T cells occurs, which results in the production of a certain pattern of cytokines. These cytokines influence the expression of cell surface antigens and adhesion molecules, and are able to activate other cell types such as cytotoxic T cells, macrophages and natural killer cells, which might act as effector cells in tissue destruction. Insight into the sequential expression of the various cytokines involved might enable a more effective treatment of GVHD. Therefore, we investigated the occurrence of cytokines in a murine model for acute GVHD. We addressed in particular the period early after allogeneic reconstitution.

M3 - Article

VL - 5

SP - 679-680.

JO - Transplant International

T2 - Transplant International

JF - Transplant International

SN - 0934-0874

ER -

Knulst AC, Bril-Bazuin C, Tibbe GJM, van Oudenaren A, Savelkoul HFJ, Benner R. Cytokines in lethal graft-versus-host disease. Transplant International. 1992;5:679-680.