CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol and cafestol interventions in humans.

M.K. Hofman, R.M. Weggemans, P.L. Zock, E.G. Schouten, M.B. Katan, H.M.G. Princen

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Abstract

The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important in these interindividual differences. The rate-limiting enzyme in the conversion of cholesterol into bile acids is cholesterol 7-hydroxylase (CYP7A1). We investigated the effect of the A278-C promoter polymorphism in the CYP7A1 gene on responses of plasma lipids to an increased intake in dietary cholesterol (742 ± 114 mg/d), cafestol (57 ± 6 mg/d), saturated fat [change of 8¿9 energy percent/d (en%/d)] and trans fat (change of 10¿11 en%/d) in 496 normolipidemic subjects. These responses were measured in 26 previously published dietary trials. After adjustment for the apolipoprotein E genotype effect, AA-subjects consuming a cholesterol-rich diet had a smaller increase in plasma HDL cholesterol than CC-subjects (0.00 ± 0.02 vs. 0.17 ± 0.04 mmol/L; P <0.001). Upon intake of cafestol, AA-subjects had a smaller increase in plasma total cholesterol than CC-subjects (0.69 ± 0.10 vs. 1.01 ± 0.10 mmol/L; P = 0.028). No effects of the polymorphism were found in the saturated and trans fat interventions. In conclusion, the CYP7A1 polymorphism has a small but significant effect on the increase in plasma HDL cholesterol and plasma total cholesterol after an increased intake of dietary cholesterol and cafestol, respectively
Original languageEnglish
Pages (from-to)2200-2204
JournalThe Journal of Nutrition
Volume134
Issue number9
DOIs
Publication statusPublished - Sep 2004

Keywords

  • density-lipoprotein cholesterol
  • 7 alpha-hydroxylase
  • bile-acid synthesis
  • trans-fatty-acids
  • serum-cholesterol
  • boiled coffee
  • 7-alpha-hydroxylase gene
  • liver aminotransferases
  • sterol 27-hydroxylase
  • raising factor

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    Hofman, M. K., Weggemans, R. M., Zock, P. L., Schouten, E. G., Katan, M. B., & Princen, H. M. G. (2004). CYP7A1 A-278C polymorphism affects the response of plasma lipids after dietary cholesterol and cafestol interventions in humans. The Journal of Nutrition, 134(9), 2200-2204. https://doi.org/10.1093/jn/134.9.2200