Cyclic lipopeptide production by plant-associated Pseudomonas spp.: diversity, activity, biosynthesis, and regulation

J.M. Raaijmakers, I. de Bruijn, M.J.D. de Kock

Research output: Contribution to journalArticleAcademicpeer-review

265 Citations (Scopus)

Abstract

Cyclic lipopeptides (CLPs) are versatile molecules produced by a variety of bacterial genera, including plant-associated Pseudomonas spp. CLPs are composed of a fatty acid tail linked to a short oligopeptide, which is cyclized to form a lactone ring between two amino acids in the peptide chain. CLPs are very diverse both structurally and in terms of their biological activity. The structural diversity is due to differences in the length and composition of the fatty acid tail and to variations in the number, type, and configuration of the amino acids in the peptide moiety. CLPs have received considerable attention for their antimicrobial, cytotoxic, and surfactant properties. For plant-pathogenic Pseudomonas spp., CLPs constitute important virulence factors, and pore formation, followed by cell lysis, is their main mode of action. For the antagonistic Pseudomonas sp., CLPs play a key role in antimicrobial activity, motility, and biofilm formation. CLPs are produced via nonribosomal synthesis on large, multifunctional peptide synthetases. Both the structural organization of the CLP synthetic templates and the presence of specific domains and signature sequences within peptide synthetase genes will be described for both pathogenic and antagonistic Pseudomonas spp. Finally, the role of various genes and regulatory mechanisms in CLP production by Pseudomonas spp., including two-component regulation and quorum sensing, will be discussed in detail. Additional keywords: Bacillus, nonribosomal peptide synthesis
Original languageEnglish
Pages (from-to)699-710
JournalMolecular Plant-Microbe Interactions
Volume19
Issue number7
DOIs
Publication statusPublished - 2006

Fingerprint

lipopeptides
Lipopeptides
Pseudomonas
biosynthesis
peptides
Peptide Synthases
ligases
Peptides
tail
Fatty Acids
anti-infective agents
Amino Acids
Quorum Sensing
oligopeptides
Oligopeptides
amino acids
quorum sensing
synthesis
Virulence Factors
Lactones

Keywords

  • syringae pv.-syringae
  • nonribosomal peptide synthetases
  • brown blotch disease
  • sugar-beet rhizosphere
  • channel-forming activities
  • sp strain dss73
  • gene-cluster
  • bacillus-subtilis
  • biofilm formation
  • fluorescens dr54

Cite this

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title = "Cyclic lipopeptide production by plant-associated Pseudomonas spp.: diversity, activity, biosynthesis, and regulation",
abstract = "Cyclic lipopeptides (CLPs) are versatile molecules produced by a variety of bacterial genera, including plant-associated Pseudomonas spp. CLPs are composed of a fatty acid tail linked to a short oligopeptide, which is cyclized to form a lactone ring between two amino acids in the peptide chain. CLPs are very diverse both structurally and in terms of their biological activity. The structural diversity is due to differences in the length and composition of the fatty acid tail and to variations in the number, type, and configuration of the amino acids in the peptide moiety. CLPs have received considerable attention for their antimicrobial, cytotoxic, and surfactant properties. For plant-pathogenic Pseudomonas spp., CLPs constitute important virulence factors, and pore formation, followed by cell lysis, is their main mode of action. For the antagonistic Pseudomonas sp., CLPs play a key role in antimicrobial activity, motility, and biofilm formation. CLPs are produced via nonribosomal synthesis on large, multifunctional peptide synthetases. Both the structural organization of the CLP synthetic templates and the presence of specific domains and signature sequences within peptide synthetase genes will be described for both pathogenic and antagonistic Pseudomonas spp. Finally, the role of various genes and regulatory mechanisms in CLP production by Pseudomonas spp., including two-component regulation and quorum sensing, will be discussed in detail. Additional keywords: Bacillus, nonribosomal peptide synthesis",
keywords = "syringae pv.-syringae, nonribosomal peptide synthetases, brown blotch disease, sugar-beet rhizosphere, channel-forming activities, sp strain dss73, gene-cluster, bacillus-subtilis, biofilm formation, fluorescens dr54",
author = "J.M. Raaijmakers and {de Bruijn}, I. and {de Kock}, M.J.D.",
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}

Cyclic lipopeptide production by plant-associated Pseudomonas spp.: diversity, activity, biosynthesis, and regulation. / Raaijmakers, J.M.; de Bruijn, I.; de Kock, M.J.D.

In: Molecular Plant-Microbe Interactions, Vol. 19, No. 7, 2006, p. 699-710.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

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AU - de Kock, M.J.D.

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