Cycles and interactions: A mathematician among biologists

Pablo Rodríguez-Sánchez

Research output: Thesisinternal PhD, WU


The backbone of this thesis is the interdisciplinary interaction between dynamic systems theory and a selection of biological problems. Each chapter focuses in one problem, namely plankton dynamics, cell development paths and sleep-wake dynamics. Despite these topics may seem disconnected, they share an important feature: all of them show cyclic behaviour under certain circumstances.
In the present thesis we show that cyclic (or chaotic) behaviour is deeply related with plankton biodiversity. We also use cycles to show, in an intuitive way, that Waddington’s epigenetic landscapes (a common visual tool in stem cell research) are poorly defined, and we provide a practical solution to this. Lastly, we provide an algorithm to forecast a transition between synchronized and non-synchronized cyclic systems (such as normal sleep – insomnia, or normal hearth functioning – arrhythmia), with potential applications in medical sciences.

Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Wageningen University
  • Scheffer, Marten, Promotor
  • van Nes, Egbert, Co-promotor
Award date15 Jun 2020
Place of PublicationWageningen
Print ISBNs9789463953931
Publication statusPublished - 2020


Dive into the research topics of 'Cycles and interactions: A mathematician among biologists'. Together they form a unique fingerprint.

Cite this