CRISPR-associated base-editing of the complementary strand

John Van Der Oost; Wen Ying Wu; Ricardo Villegas Warren

CRISPR-associated base-editing of the complementary strand

John Van Der Oost (Inventor), Wen Ying Wu (Inventor), Ricardo Villegas Warren (Inventor)

Research output: Patent

Abstract

The invention relates to methods for clustered regularly interspaced short palindromic repeat (CRISPR)-mediated A to G and/or C to T editing of the guide- complementary strand of a double stranded target DNA. The invention further relates to a nucleotide molecule encoding said CRISPR-mediated base editing system, to an expression vector comprising the nucleotide molecule, and to a cell comprising the expression vector. The invention further relates to an isolated Cas nuclease that allows A to G and/or C to T editing of the complementary strand of a double stranded target nucleic acid.

Original language	English
Patent number	WO2022164319
Priority date	1/04/21
Publication status	Published - 4 Aug 2022

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title = "CRISPR-associated base-editing of the complementary strand",

abstract = "The invention relates to methods for clustered regularly interspaced short palindromic repeat (CRISPR)-mediated A to G and/or C to T editing of the guide- complementary strand of a double stranded target DNA. The invention further relates to a nucleotide molecule encoding said CRISPR-mediated base editing system, to an expression vector comprising the nucleotide molecule, and to a cell comprising the expression vector. The invention further relates to an isolated Cas nuclease that allows A to G and/or C to T editing of the complementary strand of a double stranded target nucleic acid.",

author = "{Van Der Oost}, John and Wu, {Wen Ying} and {Villegas Warren}, Ricardo",

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language = "English",

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T1 - CRISPR-associated base-editing of the complementary strand

AU - Van Der Oost, John

AU - Wu, Wen Ying

AU - Villegas Warren, Ricardo

PY - 2022/8/4

Y1 - 2022/8/4

N2 - The invention relates to methods for clustered regularly interspaced short palindromic repeat (CRISPR)-mediated A to G and/or C to T editing of the guide- complementary strand of a double stranded target DNA. The invention further relates to a nucleotide molecule encoding said CRISPR-mediated base editing system, to an expression vector comprising the nucleotide molecule, and to a cell comprising the expression vector. The invention further relates to an isolated Cas nuclease that allows A to G and/or C to T editing of the complementary strand of a double stranded target nucleic acid.

AB - The invention relates to methods for clustered regularly interspaced short palindromic repeat (CRISPR)-mediated A to G and/or C to T editing of the guide- complementary strand of a double stranded target DNA. The invention further relates to a nucleotide molecule encoding said CRISPR-mediated base editing system, to an expression vector comprising the nucleotide molecule, and to a cell comprising the expression vector. The invention further relates to an isolated Cas nuclease that allows A to G and/or C to T editing of the complementary strand of a double stranded target nucleic acid.

M3 - Patent

M1 - WO2022164319

ER -

CRISPR-associated base-editing of the complementary strand

Abstract

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