Abstract
The cAMP/PKA signalling pathway and transcription factor cAMP response element-binding protein (CREB) play key roles in long-term memory (LTM) formation. We used two closely related parasitic wasp species, Cotesia glomerata and Cotesia rubecula, which were previously shown to be different in LTM formation, and sequenced at least nine different CREB transcripts in both wasp species. The splicing patterns, functional domains and amino acid sequences were similar to those found in the CREB genes of other organisms. The predicted amino acid sequences of the CREB isoforms were identical in both wasp species. Using real-time quantitative PCR we found that two low abundant CREB transcripts are differentially expressed in the two wasps, whereas the expression levels of high abundant transcripts are similar.
| Original language | English |
|---|---|
| Pages (from-to) | 367-379 |
| Journal | Insect Molecular Biology |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2010 |
Keywords
- element-binding-protein
- camp-response element
- transcription factor creb
- central-nervous-system
- snail lymnaea-stagnalis
- cyclic-amp
- messenger-rna
- cotesia-glomerata
- drosophila-melanogaster
- targeted mutation
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Cotesia CREB1 isoform protein (CREB) mRNA, complete cds, alternatively spliced
van den Berg, M. (Creator), Verbaarschot, P. G. H. (Creator), Hontelez, S. (Creator), Vet, L. E. M. (Creator), Dicke, M. (Creator) & Smid, H. M. (Creator), Wageningen University & Research, 27 May 2010
https://www.ncbi.nlm.nih.gov/popset/205361470
Dataset