Coronary microvascular dysfunction during long term metabolic derangement in swine

O. Sorop, M. van den Heuvel, V.J. de Beer, N.S. van Ditzhuijzen, I.M. Heinonen, D. Merkus, S.J. Koopmans, A.H.J. Danser, D.J. Duncker

Research output: Contribution to journalAbstractAcademic


Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 µm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P
Original languageEnglish
Pages (from-to)271-271
JournalCardiovascular Research
Issue numberS49
Publication statusPublished - 2014


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