Coronary microvascular dysfunction during long term metabolic derangement in swine

O. Sorop; M. van den Heuvel; V.J. de Beer; N.S. van Ditzhuijzen; I.M. Heinonen; D. Merkus; S.J. Koopmans; A.H.J. Danser; D.J. Duncker

doi:10.1093/cvr/cvu084.1

Coronary microvascular dysfunction during long term metabolic derangement in swine

O. Sorop, M. van den Heuvel, V.J. de Beer, N.S. van Ditzhuijzen, I.M. Heinonen, D. Merkus, S.J. Koopmans, A.H.J. Danser, D.J. Duncker

Research output: Contribution to journal › Abstract › Academic

Abstract

Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 µm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P

Original language	English
Pages (from-to)	271-271
Journal	Cardiovascular Research
Volume	103
Issue number	S49
DOIs	https://doi.org/10.1093/cvr/cvu084.1
Publication status	Published - 2014

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10.1093/cvr/cvu084.1

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title = "Coronary microvascular dysfunction during long term metabolic derangement in swine",

abstract = "Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 µm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P",

author = "O. Sorop and {van den Heuvel}, M. and {de Beer}, V.J. and {van Ditzhuijzen}, N.S. and I.M. Heinonen and D. Merkus and S.J. Koopmans and A.H.J. Danser and D.J. Duncker",

year = "2014",

doi = "10.1093/cvr/cvu084.1",

language = "English",

volume = "103",

pages = "271--271",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

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T1 - Coronary microvascular dysfunction during long term metabolic derangement in swine

AU - Sorop, O.

AU - van den Heuvel, M.

AU - de Beer, V.J.

AU - van Ditzhuijzen, N.S.

AU - Heinonen, I.M.

AU - Merkus, D.

AU - Koopmans, S.J.

AU - Danser, A.H.J.

AU - Duncker, D.J.

PY - 2014

Y1 - 2014

N2 - Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 µm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P

AB - Dysfunction of the coronary microvasculature has been proposed as one of the important contributors to the diabetes mellitus (DM) associated coronary artery disease (CAD). How different aspects of such dysfunction manifest during disease progression remains incompletely understood. Therefore we studied the time course of coronary microvascular dysfunction in a large animal model of metabolic derangement. Swine with streptozotocin-induced DM type II were fed a high fat diet for up to 15 mo. Coronary small arteries (300 µm) were studied in vitro at 2mo (n=6), 6mo (n=7) and 15 mo (n=5) follow up and compared to healthy controls (n=12, Control). All diabetic groups showed marked hyperglycemia (16±3, 18±4 and 18±1 mmol/l at 2mo, 6mo and 15mo resp.) and hypercholesterolemia (14±2, 17±2 and 18±3 mmol/l) as compared to Control (glucose: 5±1 and cholesterol: 2.0±0.3 mmol/l; all P

U2 - 10.1093/cvr/cvu084.1

DO - 10.1093/cvr/cvu084.1

M3 - Abstract

SN - 0008-6363

VL - 103

SP - 271

EP - 271

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - S49

ER -

Coronary microvascular dysfunction during long term metabolic derangement in swine

Abstract

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