Core-shell γ-Fe2O3/SiO2/PCA/Ag-NPs hybrid nanomaterials as a new candidate for future cancer therapy

R. Soleyman, A. Pourjavadi, N. Masoud, A. Varamesh

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2 Citations (Scopus)

Abstract

In the current study, γ-Fe2O3/SiO 2/PCA/Ag-NPs hybrid nanomaterials were successfully synthesized and characterized. At first, prepared γ-Fe2O3 core nanoparticles were modified by SiO2 layer. Then they were covered by poly citric acid (PCA) via melting esterification method as well. PCA shell acts as an effective linker, and provides vacancies for conveying drugs. Moreover, this shell as an effective capping agent directs synthesis of silver nanoparticles (Ag-NPs) via in situ photo-reduction of silver ions by sunlight-UV irradiation. This system has several benefits as a suitable cancer therapy nanomaterial. Magnetic nanoparticles (MNPs) can guide Ag-NPs and drugs to cancer cells and then Ag-NPs can affect those cells via Ag-NPs anti-angiogenesis effect. Size and structure of the prepared magnetic hybrid nanomaterials were characterized using FTIR and UV-Vis spectra, AFM and TEM pictures and XRD data.

Original languageEnglish
Article number1450008
JournalInternational Journal of Nanoscience
Volume13
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

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Keywords

  • Hybrid nanomaterials
  • poly citric acid
  • silver nanoparticles

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