Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice

M. Marco, M.C. de Vries, M.W.W. Wels, D. Molenaar, P. Mangell, S. Ahrne, W.M. de Vos, E.E. Vaughan, M. Kleerebezem

Research output: Contribution to journalArticleAcademicpeer-review

67 Citations (Scopus)

Abstract

Probiotic bacteria provide unique opportunities to study the global responses and molecular mechanisms underlying the effects of gut-associated microorganisms in the human digestive tract. In this study, we show by comparative transcriptome analysis using DNA microarrays that the established probiotic Lactobacillus plantarum 299v specifically adapts its metabolic capacity in the human intestine for carbohydrate acquisition and expression of exopolysaccharide and proteinaceous cell surface compounds. This report constitutes the first application of global gene expression profiling of a commensal microorganism in the human gut. A core L. plantarum transcriptome expressed in the mammalian intestine was also determined through comparisons of L. plantarum 299v activities in humans to those found for L. plantarum WCFS1 in germ-free mice. These results identify the niche-specific adaptations of a dietary microorganism to the intestinal ecosystem and provide novel targets for molecular analysis of microbial-host interactions which affect human health
Original languageEnglish
Pages (from-to)1481-1484
JournalISME Journal
Volume4
Issue number11
DOIs
Publication statusPublished - 2010

Keywords

  • gastrointestinal-tract
  • plantarum wcfs1
  • genes

Fingerprint Dive into the research topics of 'Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice'. Together they form a unique fingerprint.

  • Cite this

    Marco, M., de Vries, M. C., Wels, M. W. W., Molenaar, D., Mangell, P., Ahrne, S., ... Kleerebezem, M. (2010). Convergence in probiotic Lactobacillus gut-adaptive responses in humans and mice. ISME Journal, 4(11), 1481-1484. https://doi.org/10.1038/ismej.2010.61