Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands

Helen J. Esser*, Stephanie M. Lim, Ankje de Vries, Hein Sprong, Dinant J. Dekker, Emily L. Pascoe, Julian W. Bakker, Vanessa Suin, Eelco Franz, Byron E.E. Martina, Constantianus J.M. Koenraadt

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Tick-borne encephalitis virus (TBEV) is an emerging pathogen that was first detected in ticks and humans in the Netherlands in 2015 (ticks) and 2016 (humans). To learn more about its distribution and prevalence in the Netherlands, we conducted large-scale surveillance in ticks and rodents during August 2018–September 2020. We tested 320 wild rodents and >46,000 ticks from 48 locations considered to be at high risk for TBEV circulation. We found TBEV RNA in 3 rodents (0.9%) and 7 tick pools (minimum infection rate 0.02%) from 5 geographically distinct foci. Phylogenetic analyses indicated that 3 different variants of the TBEV-Eu subtype circulate in the Netherlands, suggesting multiple independent introductions. Combined with recent human cases outside known TBEV hotspots, our data demonstrate that the distribution of TBEV in the Netherlands is more widespread than previously thought.

Original languageEnglish
Pages (from-to)2416-2424
JournalEmerging Infectious Diseases
Volume28
Issue number12
DOIs
Publication statusPublished - Dec 2022

Fingerprint

Dive into the research topics of 'Continued Circulation of Tick-Borne Encephalitis Virus Variants and Detection of Novel Transmission Foci, the Netherlands'. Together they form a unique fingerprint.

Cite this