Construction and Application of Newcastle Disease Virus-Based Vector Vaccines

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

1 Citation (Scopus)


Paramyxoviruses are able to stably express a wide-variety of heterologous antigens at relatively high levels in various species and are consequently considered as potent gene delivery vehicles. A single vaccination is frequently sufficient for the induction of robust humoral and cellular immune responses. Here we provide detailed methods for the construction and application of Newcastle disease virus (NDV)-based vector vaccines. The in silico design and in vitro rescue as well as the in vivo evaluation of NDV based vectors are described in this chapter.
Original languageEnglish
Title of host publicationVaccine Technologies for Veterinary Viral Diseases
EditorsA. Brun
ISBN (Electronic)9781493930081
ISBN (Print)9781493930074
Publication statusPublished - 2016

Publication series

NameMethodes in Molecular Biology

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