Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.

J. Kaput, B. van Ommen, B. Kremer, C. Priami, J. Pontes Monteiro, M. Morine, F. Pepping, Z. Diaz, M. Fenech, Y. He, R. Albers, C.A. Drevon, C.T. Evelo, R.E.W. Hancock, C. Ijsselmuiden, L.H. Lumey, A.M. Minihane, M.R. Muller, C. Murgia, M. Radonjic & 2 others B.W.S. Sobral, K.P. West Jr.

Research output: Contribution to journalEditorialAcademicpeer-review

14 Citations (Scopus)

Abstract

Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
Original languageEnglish
Article number378
Number of pages9
JournalGenes & Nutrition
Volume9
Issue number9
DOIs
Publication statusPublished - 2014

Fingerprint

Systems Analysis
Malnutrition
Food
Physiological Phenomena
Health
Growth
Research
Biological Phenomena
Knowledge Bases
Social Environment
Social Conditions
Biological Factors
Biomedical Research
Technology
Peptides
Population

Keywords

  • birth-weight infants
  • developing-countries
  • global health
  • environmental enteropathy
  • participatory research
  • grand challenges
  • innate immunity
  • trace-elements
  • biology
  • nutrition

Cite this

Kaput, J., van Ommen, B., Kremer, B., Priami, C., Pontes Monteiro, J., Morine, M., ... West Jr., K. P. (2014). Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life. Genes & Nutrition, 9(9), [378]. https://doi.org/10.1007/s12263-013-0378-y
Kaput, J. ; van Ommen, B. ; Kremer, B. ; Priami, C. ; Pontes Monteiro, J. ; Morine, M. ; Pepping, F. ; Diaz, Z. ; Fenech, M. ; He, Y. ; Albers, R. ; Drevon, C.A. ; Evelo, C.T. ; Hancock, R.E.W. ; Ijsselmuiden, C. ; Lumey, L.H. ; Minihane, A.M. ; Muller, M.R. ; Murgia, C. ; Radonjic, M. ; Sobral, B.W.S. ; West Jr., K.P. / Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life. In: Genes & Nutrition. 2014 ; Vol. 9, No. 9.
@article{34ac9743efb54c9181d3f22b5e631275,
title = "Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.",
abstract = "Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.",
keywords = "birth-weight infants, developing-countries, global health, environmental enteropathy, participatory research, grand challenges, innate immunity, trace-elements, biology, nutrition",
author = "J. Kaput and {van Ommen}, B. and B. Kremer and C. Priami and {Pontes Monteiro}, J. and M. Morine and F. Pepping and Z. Diaz and M. Fenech and Y. He and R. Albers and C.A. Drevon and C.T. Evelo and R.E.W. Hancock and C. Ijsselmuiden and L.H. Lumey and A.M. Minihane and M.R. Muller and C. Murgia and M. Radonjic and B.W.S. Sobral and {West Jr.}, K.P.",
year = "2014",
doi = "10.1007/s12263-013-0378-y",
language = "English",
volume = "9",
journal = "Genes & Nutrition",
issn = "1555-8932",
publisher = "Springer Verlag",
number = "9",

}

Kaput, J, van Ommen, B, Kremer, B, Priami, C, Pontes Monteiro, J, Morine, M, Pepping, F, Diaz, Z, Fenech, M, He, Y, Albers, R, Drevon, CA, Evelo, CT, Hancock, REW, Ijsselmuiden, C, Lumey, LH, Minihane, AM, Muller, MR, Murgia, C, Radonjic, M, Sobral, BWS & West Jr., KP 2014, 'Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.' Genes & Nutrition, vol. 9, no. 9, 378. https://doi.org/10.1007/s12263-013-0378-y

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life. / Kaput, J.; van Ommen, B.; Kremer, B.; Priami, C.; Pontes Monteiro, J.; Morine, M.; Pepping, F.; Diaz, Z.; Fenech, M.; He, Y.; Albers, R.; Drevon, C.A.; Evelo, C.T.; Hancock, R.E.W.; Ijsselmuiden, C.; Lumey, L.H.; Minihane, A.M.; Muller, M.R.; Murgia, C.; Radonjic, M.; Sobral, B.W.S.; West Jr., K.P.

In: Genes & Nutrition, Vol. 9, No. 9, 378, 2014.

Research output: Contribution to journalEditorialAcademicpeer-review

TY - JOUR

T1 - Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.

AU - Kaput, J.

AU - van Ommen, B.

AU - Kremer, B.

AU - Priami, C.

AU - Pontes Monteiro, J.

AU - Morine, M.

AU - Pepping, F.

AU - Diaz, Z.

AU - Fenech, M.

AU - He, Y.

AU - Albers, R.

AU - Drevon, C.A.

AU - Evelo, C.T.

AU - Hancock, R.E.W.

AU - Ijsselmuiden, C.

AU - Lumey, L.H.

AU - Minihane, A.M.

AU - Muller, M.R.

AU - Murgia, C.

AU - Radonjic, M.

AU - Sobral, B.W.S.

AU - West Jr., K.P.

PY - 2014

Y1 - 2014

N2 - Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.

AB - Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.

KW - birth-weight infants

KW - developing-countries

KW - global health

KW - environmental enteropathy

KW - participatory research

KW - grand challenges

KW - innate immunity

KW - trace-elements

KW - biology

KW - nutrition

U2 - 10.1007/s12263-013-0378-y

DO - 10.1007/s12263-013-0378-y

M3 - Editorial

VL - 9

JO - Genes & Nutrition

JF - Genes & Nutrition

SN - 1555-8932

IS - 9

M1 - 378

ER -