Consensus proposals for classification of the family Hepeviridae

D.B. Smith, P. Simmonds, S. Jameel, S.U. Emerson, T.J. Harrison, X.J. Meng, H. Okamoto, W.H.M. van der Poel, M.A. Purdy

Research output: Contribution to journalArticleAcademicpeer-review

325 Citations (Scopus)

Abstract

The family Hepeviridae consists of positive-stranded RNA viruses that infect a wide range of mammalian species, as well as chickens and trout. A subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. Current published descriptions of the taxonomical divisions within the family Hepeviridae are contradictory in relation to the assignment of species and genotypes. Through analysis of existing sequence information, we propose a taxonomic scheme in which the family is divided into the genera Orthohepevirus (all mammalian and avian hepatitis E virus (HEV) isolates) and Piscihepevirus (cutthroat trout virus). Species within the genus Orthohepevirus are designated Orthohepevirus A (isolates from human, pig, wild boar, deer, mongoose, rabbit and camel), Orthohepevirus B (isolates from chicken), Orthohepevirus C (isolates from rat, greater bandicoot, Asian musk shrew, ferret and mink) and Orthohepevirus D (isolates from bat). Proposals are also made for the designation of genotypes within the human and rat HEVs. This hierarchical system is congruent with hepevirus phylogeny, and the three classification levels (genus, species and genotype) are consistent with, and reflect discontinuities in the ranges of pairwise distances between amino acid sequences. Adoption of this system would include the avoidance of host names in taxonomic identifiers and provide a logical framework for the assignment of novel variants.
Original languageEnglish
Pages (from-to)2223-2232
JournalJournal of General Virology
Volume95
DOIs
Publication statusPublished - 2014

Fingerprint

Hepevirus
Trout
Genotype
Chickens
Herpestidae
Shrews
Viruses
Murinae
Mink
Camelus
Sus scrofa
Ferrets
Deer
RNA Viruses
Phylogeny
Hepatitis
Names
Sequence Analysis
Amino Acid Sequence
Swine

Keywords

  • hepatitis-e virus
  • genetic-variability
  • phylogenetic analysis
  • molecular-cloning
  • wild rats
  • c virus
  • hev
  • genotype
  • china
  • recombination

Cite this

Smith, D. B., Simmonds, P., Jameel, S., Emerson, S. U., Harrison, T. J., Meng, X. J., ... Purdy, M. A. (2014). Consensus proposals for classification of the family Hepeviridae. Journal of General Virology, 95, 2223-2232. https://doi.org/10.1099/vir.0.068429-0
Smith, D.B. ; Simmonds, P. ; Jameel, S. ; Emerson, S.U. ; Harrison, T.J. ; Meng, X.J. ; Okamoto, H. ; van der Poel, W.H.M. ; Purdy, M.A. / Consensus proposals for classification of the family Hepeviridae. In: Journal of General Virology. 2014 ; Vol. 95. pp. 2223-2232.
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Smith, DB, Simmonds, P, Jameel, S, Emerson, SU, Harrison, TJ, Meng, XJ, Okamoto, H, van der Poel, WHM & Purdy, MA 2014, 'Consensus proposals for classification of the family Hepeviridae', Journal of General Virology, vol. 95, pp. 2223-2232. https://doi.org/10.1099/vir.0.068429-0

Consensus proposals for classification of the family Hepeviridae. / Smith, D.B.; Simmonds, P.; Jameel, S.; Emerson, S.U.; Harrison, T.J.; Meng, X.J.; Okamoto, H.; van der Poel, W.H.M.; Purdy, M.A.

In: Journal of General Virology, Vol. 95, 2014, p. 2223-2232.

Research output: Contribution to journalArticleAcademicpeer-review

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AU - Smith, D.B.

AU - Simmonds, P.

AU - Jameel, S.

AU - Emerson, S.U.

AU - Harrison, T.J.

AU - Meng, X.J.

AU - Okamoto, H.

AU - van der Poel, W.H.M.

AU - Purdy, M.A.

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N2 - The family Hepeviridae consists of positive-stranded RNA viruses that infect a wide range of mammalian species, as well as chickens and trout. A subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. Current published descriptions of the taxonomical divisions within the family Hepeviridae are contradictory in relation to the assignment of species and genotypes. Through analysis of existing sequence information, we propose a taxonomic scheme in which the family is divided into the genera Orthohepevirus (all mammalian and avian hepatitis E virus (HEV) isolates) and Piscihepevirus (cutthroat trout virus). Species within the genus Orthohepevirus are designated Orthohepevirus A (isolates from human, pig, wild boar, deer, mongoose, rabbit and camel), Orthohepevirus B (isolates from chicken), Orthohepevirus C (isolates from rat, greater bandicoot, Asian musk shrew, ferret and mink) and Orthohepevirus D (isolates from bat). Proposals are also made for the designation of genotypes within the human and rat HEVs. This hierarchical system is congruent with hepevirus phylogeny, and the three classification levels (genus, species and genotype) are consistent with, and reflect discontinuities in the ranges of pairwise distances between amino acid sequences. Adoption of this system would include the avoidance of host names in taxonomic identifiers and provide a logical framework for the assignment of novel variants.

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KW - hepatitis-e virus

KW - genetic-variability

KW - phylogenetic analysis

KW - molecular-cloning

KW - wild rats

KW - c virus

KW - hev

KW - genotype

KW - china

KW - recombination

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DO - 10.1099/vir.0.068429-0

M3 - Article

VL - 95

SP - 2223

EP - 2232

JO - Journal of General Virology

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SN - 0022-1317

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Smith DB, Simmonds P, Jameel S, Emerson SU, Harrison TJ, Meng XJ et al. Consensus proposals for classification of the family Hepeviridae. Journal of General Virology. 2014;95:2223-2232. https://doi.org/10.1099/vir.0.068429-0