Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin

M. de Kort, B. Gianotten, J. Wisse, E. Bos, M.H.M. Eppink, E. Mattaar, G. Vogel, W. Dokter, M. Honing, S. Vonsovic, M. Smit, J. Wijkmans, S. van Boeckel

Research output: Contribution to journalArticleAcademicpeer-review

16 Citations (Scopus)
Original languageEnglish
Pages (from-to)1189-1193
JournalChemMedChem : chemistry enabling drug discovery
Issue number8
Publication statusPublished - 2008


  • human serum-albumin
  • antithrombin-iii
  • fondaparinux sodium
  • heparin pentasaccharide
  • biological-properties
  • in-vivo
  • pegylation
  • analogs
  • drug
  • delivery

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