Concordance with the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention and colorectal cancer risk in Morocco: A large, population-based case–control study

Khaoula El Kinany*, Inge Huybrechts, Ellen Kampman, Hanae Abir Boudouaya, Zineb Hatime, Meimouna Mint Sidi Deoula, Achraf El Asri, Abdelilah Benslimane, Chakib Nejjari, Sidi Adil Ibrahimi, Hind Mrabti, Naima Abda, Rhimou Alaoui, Marc J. Gunter, Karima El Rhazi

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

The present study aimed to investigate associations between adherence to the recommendations on cancer prevention from the WCRF/AICR and colorectal cancer (CRC) risk in Morocco. Incident CRC cases (n = 1,516) and controls (n = 1,516) matched on age, sex and center, were recruited between September 2009 and February 2017 at five major hospitals located in Morocco. In-person interviews were conducted to assess habitual diet using a validated Food Frequency Questionnaire, physical activity and anthropometric measurements. Adherence to the WCRF/AIRC Recommendations was ranged from 0 (no adherence) to 6 (maximal adherence) and incorporating six WCRF/AICR components (food groups, physical activity and BMI). Multivariable odd ratios (OR A ) and 95% confidence intervals (CI) were calculated using conditional multivariate logistic regression models, with low adherence as referent, adjusting for potential confounding factors. Compared to those with the lowest adherence score, individuals in the highest WCRF/AICR score category had a statistically significant reduced risk for colon cancer (OR A = 0.63, 95% CI 0.53–0.76); rectal cancer (OR A = 0.52, 95% CI 0.43–0.63) and CRC overall (OR A = 0.58, 95% CI 0.51–0.66). For individual score components, when comparing the lowest with the highest adherence category, CRC risk was significantly lower in the highest adherence category for body fatness (OR A = 0.73; 95% CI 0.62–0.85), physical activity (OR A = 0.70; 95% CI 0.60–0.82), plant foods (OR A = 0.50; 95% CI 0.39–0.63) and red/processed meat (OR A = 0.81; 95% CI 0.71–0.92). Our analysis indicated that greater adherence to the WCRF/AICR recommendations for cancer prevention may lower CRC risk in Morocco.

Original languageEnglish
JournalInternational Journal of Cancer
DOIs
Publication statusE-pub ahead of print - 12 Mar 2019

Keywords

  • case–control study, FFQ, Morocco
  • colorectal cancer
  • WCRF/AICR recommendations

Fingerprint Dive into the research topics of 'Concordance with the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention and colorectal cancer risk in Morocco: A large, population-based case–control study'. Together they form a unique fingerprint.

  • Cite this

    El Kinany, K., Huybrechts, I., Kampman, E., Boudouaya, H. A., Hatime, Z., Mint Sidi Deoula, M., El Asri, A., Benslimane, A., Nejjari, C., Ibrahimi, S. A., Mrabti, H., Abda, N., Alaoui, R., Gunter, M. J., & El Rhazi, K. (2019). Concordance with the World Cancer Research Fund/American Institute for Cancer Research recommendations for cancer prevention and colorectal cancer risk in Morocco: A large, population-based case–control study. International Journal of Cancer. https://doi.org/10.1002/ijc.32263