Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS

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Ultra-performance liquid chromatography combined with time-of-flight mass spectrometry (UPLC¿ToF-MS) has been used for screening and quantification of more than 100 veterinary drugs in milk. The veterinary drugs represent different classes including benzimidazoles, macrolides, penicillins, quinolones, sulphonamides, pyrimidines, tetracylines, nitroimidazoles, tranquillizers, ionophores, amphenicols and non-steroidal anti-inflammatory agents (NSAIDs). After protein precipitation, centrifugation and solid-phase extraction (SPE), the extracts were analysed by UPLC¿ToF-MS. From the acquired full scan data the drug-specific ions were extracted for construction of the chromatograms and evaluation of the results. The analytical method was validated according to the EU guidelines (2002/657/EC) for a quantitative screening method. At the concentration level of interest (MRL level) the results for repeatability (%RSD¿
Original languageEnglish
Pages (from-to)2309-2322
JournalAnalytical and Bioanalytical Chemistry
Issue number6
Publication statusPublished - 2008


  • flight mass-spectrometry
  • growth-promoting agents
  • residue analysis
  • strategies
  • muscle
  • urine

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