Complement C3, but not C4, is independently associated with the metabolic syndrome and prevalent cardiovascular disease: the CODAM study

M.M.J. van Greevenbroek, C.J.H. van der Kallen, I. Ferreira, C.G. Schalkwijk, E.E. Blaak, E.J.M. Feskens, C.D.A. Stehouwer

Research output: Contribution to journalAbstractAcademic

Abstract

Background and aims: Increased plasma concentrations of complement C3 and C4 have been implicated in cardiovascular disease (CVD). This association may, at least partly, be related to their increase in the metabolic syndrome (MetS). C3 plays a pivotal role in complement activation via the classical, the alternative, as well as the mannan-binding lectin pathway. C4, on the other hand, is a component of the classical and the lectin pathway. Research question: Are plasma concentrations of C3 and C4 independently associated with (components of) the MetS and, if yes, are they also independently associated with CVD? Materials and methods: Relations between C3, C4, the MetS (NCEP-ATP 2005) and CVD were studied in the CODAM (cohortstudy on diabetes and atherosclerosis Maastricht) population. CODAM subjects (n=574) were selected from a large population-based cohort on the basis of an increased risk of type 2 diabetes and CVD. Associations of C3 and C4 (z-scores) with each component of the MetS were analysed using linear regression (Model(s) A: C3 or C4 as independent variables, adjusted for sex and age, with each component of the MetS as dependent variables; Model(s) B (full model): as model A but with C3 and C4 as independent variables). Associations with presence of the MetS and CVD were determined using logistic regression analyses. Results: C3 and C4 were higher (p
Original languageEnglish
Pages (from-to)S84-S85
JournalDiabetologia
Volume51
Issue numberSupp.1
Publication statusPublished - 2008

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