TY - JOUR
T1 - Complement C3, but not C4, is independently associated with the metabolic syndrome and prevalent cardiovascular disease: the CODAM study
AU - van Greevenbroek, M.M.J.
AU - van der Kallen, C.J.H.
AU - Ferreira, I.
AU - Schalkwijk, C.G.
AU - Blaak, E.E.
AU - Feskens, E.J.M.
AU - Stehouwer, C.D.A.
PY - 2008
Y1 - 2008
N2 - Background and aims: Increased plasma concentrations of complement C3 and C4 have been implicated in cardiovascular disease (CVD). This association may, at least partly, be related to their increase in the metabolic syndrome (MetS). C3 plays a pivotal role in complement activation via the classical, the alternative, as well as the mannan-binding lectin pathway. C4, on the other hand, is a component of the classical and the lectin pathway. Research question: Are plasma concentrations of C3 and C4 independently
associated with (components of) the MetS and, if yes, are they also independently
associated with CVD? Materials and methods: Relations between C3, C4, the MetS (NCEP-ATP 2005) and CVD were studied in the CODAM (cohortstudy on diabetes and
atherosclerosis Maastricht) population. CODAM subjects (n=574) were selected from a large population-based cohort on the basis of an increased risk of type 2 diabetes and CVD. Associations of C3 and C4 (z-scores) with each component of the MetS were analysed using linear regression (Model(s) A: C3 or C4 as independent variables, adjusted for sex and age, with each component of the MetS as dependent variables; Model(s) B (full model): as model A but with C3 and C4 as independent variables). Associations with presence of the MetS and CVD were determined using logistic regression analyses.
Results: C3 and C4 were higher (p
AB - Background and aims: Increased plasma concentrations of complement C3 and C4 have been implicated in cardiovascular disease (CVD). This association may, at least partly, be related to their increase in the metabolic syndrome (MetS). C3 plays a pivotal role in complement activation via the classical, the alternative, as well as the mannan-binding lectin pathway. C4, on the other hand, is a component of the classical and the lectin pathway. Research question: Are plasma concentrations of C3 and C4 independently
associated with (components of) the MetS and, if yes, are they also independently
associated with CVD? Materials and methods: Relations between C3, C4, the MetS (NCEP-ATP 2005) and CVD were studied in the CODAM (cohortstudy on diabetes and
atherosclerosis Maastricht) population. CODAM subjects (n=574) were selected from a large population-based cohort on the basis of an increased risk of type 2 diabetes and CVD. Associations of C3 and C4 (z-scores) with each component of the MetS were analysed using linear regression (Model(s) A: C3 or C4 as independent variables, adjusted for sex and age, with each component of the MetS as dependent variables; Model(s) B (full model): as model A but with C3 and C4 as independent variables). Associations with presence of the MetS and CVD were determined using logistic regression analyses.
Results: C3 and C4 were higher (p
M3 - Abstract
SN - 0012-186X
VL - 51
SP - S84-S85
JO - Diabetologia
JF - Diabetologia
IS - Supp.1
ER -