Comparison of twelve human milk oligosaccharides in mature milk from different areas in China in the Chinese Human Milk Project (CHMP) study

Wenyuan Zhang, Jacques Vervoort, Jiancun Pan, Peng Gao, Huiquan Zhu, Xiaodan Wang, Yumeng Zhang, Baorong Chen, Ying Liu, Yuanyuan Li, Xiaoyang Pang, Shuwen Zhang, Shilong Jiang*, Jing Lu, Jiaping Lyu

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Human milk oligosaccharides (HMOs) act as a vital role in the development of infant's gut microbiome and immune function. This study aimed to measure 12 oligosaccharides in milk from Chinese donors (n = 203), and evaluated the influences of multiple factors on the HMOs profiles. The results indicated that concentrations of 6′-sialyllactose were the highest among 12 oligosaccharides (2.31 ± 0.81 g/L). HMOs concentrations varied depending on geographical location. Latitude was observed to be related to concentrations of Lacto-N-neohexaose, lacto-N-fucopentaose III, 3′-sialyllactose (r = -0.67, r = +0.63 and r = +0.50, respectively). Environmental factors like seasons correlated with lacto-N-difucohexaose Ⅱ, Lacto-N-neohexaose and 2′-fucosyllactose (r = -0.47, r = -0.4, r = -0.35, respectively). Several HMOs concentrations were correlated with maternal diet. As a consequence, the HMOs profiles measured were influenced by geographical, environmental, maternal anthropometric as well as dietary factors.

Original languageEnglish
Article number133554
JournalFood Chemistry
Volume395
DOIs
Publication statusPublished - 30 Nov 2022

Keywords

  • Environment factors
  • Geography
  • Human milk oligosaccharides
  • Lactation
  • Latitude
  • Maternal diet

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