Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar, Roby Joehanes, Bonnie R. Joubert, Cheng Jian Xu, Marta Vives-Usano, Faisal I. Rezwan, Janine F. Felix, James M. Ward, Weihua Guan, Rebecca C. Richmond, Jennifer A. Brody, Leanne K. Küpers, Nour Baïz, Siri E. Håberg, Jennifer A. Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A. Markunas & 40 others Tao Xu, Lindsay M. Reynolds, Allan C. Just, Pooja R. Mandaviya, Akram Ghantous, Brian D. Bennett, Tianyuan Wang, The Bios Consortium, Kelly M. Bakulski, Erik Melen, Shanshan Zhao, Jianping Jin, Zdenko Herceg, Joyce Van Meurs, Jack A. Taylor, Andrea A. Baccarelli, Susan K. Murphy, Yongmei Liu, Monica Cheng Munthe-Kaas, Ian J. Deary, Wenche Nystad, Melanie Waldenberger, Isabella Annesi-Maesano, Karen Conneely, Vincent W.V. Jaddoe, Donna Arnett, Harold Snieder, Sharon L.R. Kardia, Caroline L. Relton, Ken K. Ong, Susan Ewart, Hortensia Moreno-Macias, Isabelle Romieu, Nona Sotoodehnia, Myriam Fornage, Alison Motsinger-Reif, Gerard H. Koppelman, Mariona Bustamante, Daniel Levy, Stephanie J. London*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

Original languageEnglish
Pages (from-to)1487-1500
Number of pages14
JournalEpigenomics
Volume11
Issue number13
DOIs
Publication statusPublished - 19 Sep 2019

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DNA Methylation
Smoking
Methylation
Pregnancy
Xenobiotics
Meta-Analysis
Mothers
Genome
Health
Genes

Keywords

  • cigarette smoking
  • epigenetics
  • infant
  • maternal exposure
  • methylation

Cite this

Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C. J., Vives-Usano, M., Rezwan, F. I., ... London, S. J. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics, 11(13), 1487-1500. https://doi.org/10.2217/epi-2019-0066
Sikdar, Sinjini ; Joehanes, Roby ; Joubert, Bonnie R. ; Xu, Cheng Jian ; Vives-Usano, Marta ; Rezwan, Faisal I. ; Felix, Janine F. ; Ward, James M. ; Guan, Weihua ; Richmond, Rebecca C. ; Brody, Jennifer A. ; Küpers, Leanne K. ; Baïz, Nour ; Håberg, Siri E. ; Smith, Jennifer A. ; Reese, Sarah E. ; Aslibekyan, Stella ; Hoyo, Cathrine ; Dhingra, Radhika ; Markunas, Christina A. ; Xu, Tao ; Reynolds, Lindsay M. ; Just, Allan C. ; Mandaviya, Pooja R. ; Ghantous, Akram ; Bennett, Brian D. ; Wang, Tianyuan ; Consortium, The Bios ; Bakulski, Kelly M. ; Melen, Erik ; Zhao, Shanshan ; Jin, Jianping ; Herceg, Zdenko ; Van Meurs, Joyce ; Taylor, Jack A. ; Baccarelli, Andrea A. ; Murphy, Susan K. ; Liu, Yongmei ; Munthe-Kaas, Monica Cheng ; Deary, Ian J. ; Nystad, Wenche ; Waldenberger, Melanie ; Annesi-Maesano, Isabella ; Conneely, Karen ; Jaddoe, Vincent W.V. ; Arnett, Donna ; Snieder, Harold ; Kardia, Sharon L.R. ; Relton, Caroline L. ; Ong, Ken K. ; Ewart, Susan ; Moreno-Macias, Hortensia ; Romieu, Isabelle ; Sotoodehnia, Nona ; Fornage, Myriam ; Motsinger-Reif, Alison ; Koppelman, Gerard H. ; Bustamante, Mariona ; Levy, Daniel ; London, Stephanie J. / Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. In: Epigenomics. 2019 ; Vol. 11, No. 13. pp. 1487-1500.
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title = "Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking",
abstract = "Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.",
keywords = "cigarette smoking, epigenetics, infant, maternal exposure, methylation",
author = "Sinjini Sikdar and Roby Joehanes and Joubert, {Bonnie R.} and Xu, {Cheng Jian} and Marta Vives-Usano and Rezwan, {Faisal I.} and Felix, {Janine F.} and Ward, {James M.} and Weihua Guan and Richmond, {Rebecca C.} and Brody, {Jennifer A.} and K{\"u}pers, {Leanne K.} and Nour Ba{\"i}z and H{\aa}berg, {Siri E.} and Smith, {Jennifer A.} and Reese, {Sarah E.} and Stella Aslibekyan and Cathrine Hoyo and Radhika Dhingra and Markunas, {Christina A.} and Tao Xu and Reynolds, {Lindsay M.} and Just, {Allan C.} and Mandaviya, {Pooja R.} and Akram Ghantous and Bennett, {Brian D.} and Tianyuan Wang and Consortium, {The Bios} and Bakulski, {Kelly M.} and Erik Melen and Shanshan Zhao and Jianping Jin and Zdenko Herceg and {Van Meurs}, Joyce and Taylor, {Jack A.} and Baccarelli, {Andrea A.} and Murphy, {Susan K.} and Yongmei Liu and Munthe-Kaas, {Monica Cheng} and Deary, {Ian J.} and Wenche Nystad and Melanie Waldenberger and Isabella Annesi-Maesano and Karen Conneely and Jaddoe, {Vincent W.V.} and Donna Arnett and Harold Snieder and Kardia, {Sharon L.R.} and Relton, {Caroline L.} and Ong, {Ken K.} and Susan Ewart and Hortensia Moreno-Macias and Isabelle Romieu and Nona Sotoodehnia and Myriam Fornage and Alison Motsinger-Reif and Koppelman, {Gerard H.} and Mariona Bustamante and Daniel Levy and London, {Stephanie J.}",
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Sikdar, S, Joehanes, R, Joubert, BR, Xu, CJ, Vives-Usano, M, Rezwan, FI, Felix, JF, Ward, JM, Guan, W, Richmond, RC, Brody, JA, Küpers, LK, Baïz, N, Håberg, SE, Smith, JA, Reese, SE, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, CA, Xu, T, Reynolds, LM, Just, AC, Mandaviya, PR, Ghantous, A, Bennett, BD, Wang, T, Consortium, TB, Bakulski, KM, Melen, E, Zhao, S, Jin, J, Herceg, Z, Van Meurs, J, Taylor, JA, Baccarelli, AA, Murphy, SK, Liu, Y, Munthe-Kaas, MC, Deary, IJ, Nystad, W, Waldenberger, M, Annesi-Maesano, I, Conneely, K, Jaddoe, VWV, Arnett, D, Snieder, H, Kardia, SLR, Relton, CL, Ong, KK, Ewart, S, Moreno-Macias, H, Romieu, I, Sotoodehnia, N, Fornage, M, Motsinger-Reif, A, Koppelman, GH, Bustamante, M, Levy, D & London, SJ 2019, 'Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking', Epigenomics, vol. 11, no. 13, pp. 1487-1500. https://doi.org/10.2217/epi-2019-0066

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. / Sikdar, Sinjini; Joehanes, Roby; Joubert, Bonnie R.; Xu, Cheng Jian; Vives-Usano, Marta; Rezwan, Faisal I.; Felix, Janine F.; Ward, James M.; Guan, Weihua; Richmond, Rebecca C.; Brody, Jennifer A.; Küpers, Leanne K.; Baïz, Nour; Håberg, Siri E.; Smith, Jennifer A.; Reese, Sarah E.; Aslibekyan, Stella; Hoyo, Cathrine; Dhingra, Radhika; Markunas, Christina A.; Xu, Tao; Reynolds, Lindsay M.; Just, Allan C.; Mandaviya, Pooja R.; Ghantous, Akram; Bennett, Brian D.; Wang, Tianyuan; Consortium, The Bios; Bakulski, Kelly M.; Melen, Erik; Zhao, Shanshan; Jin, Jianping; Herceg, Zdenko; Van Meurs, Joyce; Taylor, Jack A.; Baccarelli, Andrea A.; Murphy, Susan K.; Liu, Yongmei; Munthe-Kaas, Monica Cheng; Deary, Ian J.; Nystad, Wenche; Waldenberger, Melanie; Annesi-Maesano, Isabella; Conneely, Karen; Jaddoe, Vincent W.V.; Arnett, Donna; Snieder, Harold; Kardia, Sharon L.R.; Relton, Caroline L.; Ong, Ken K.; Ewart, Susan; Moreno-Macias, Hortensia; Romieu, Isabelle; Sotoodehnia, Nona; Fornage, Myriam; Motsinger-Reif, Alison; Koppelman, Gerard H.; Bustamante, Mariona; Levy, Daniel; London, Stephanie J.

In: Epigenomics, Vol. 11, No. 13, 19.09.2019, p. 1487-1500.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

AU - Sikdar, Sinjini

AU - Joehanes, Roby

AU - Joubert, Bonnie R.

AU - Xu, Cheng Jian

AU - Vives-Usano, Marta

AU - Rezwan, Faisal I.

AU - Felix, Janine F.

AU - Ward, James M.

AU - Guan, Weihua

AU - Richmond, Rebecca C.

AU - Brody, Jennifer A.

AU - Küpers, Leanne K.

AU - Baïz, Nour

AU - Håberg, Siri E.

AU - Smith, Jennifer A.

AU - Reese, Sarah E.

AU - Aslibekyan, Stella

AU - Hoyo, Cathrine

AU - Dhingra, Radhika

AU - Markunas, Christina A.

AU - Xu, Tao

AU - Reynolds, Lindsay M.

AU - Just, Allan C.

AU - Mandaviya, Pooja R.

AU - Ghantous, Akram

AU - Bennett, Brian D.

AU - Wang, Tianyuan

AU - Consortium, The Bios

AU - Bakulski, Kelly M.

AU - Melen, Erik

AU - Zhao, Shanshan

AU - Jin, Jianping

AU - Herceg, Zdenko

AU - Van Meurs, Joyce

AU - Taylor, Jack A.

AU - Baccarelli, Andrea A.

AU - Murphy, Susan K.

AU - Liu, Yongmei

AU - Munthe-Kaas, Monica Cheng

AU - Deary, Ian J.

AU - Nystad, Wenche

AU - Waldenberger, Melanie

AU - Annesi-Maesano, Isabella

AU - Conneely, Karen

AU - Jaddoe, Vincent W.V.

AU - Arnett, Donna

AU - Snieder, Harold

AU - Kardia, Sharon L.R.

AU - Relton, Caroline L.

AU - Ong, Ken K.

AU - Ewart, Susan

AU - Moreno-Macias, Hortensia

AU - Romieu, Isabelle

AU - Sotoodehnia, Nona

AU - Fornage, Myriam

AU - Motsinger-Reif, Alison

AU - Koppelman, Gerard H.

AU - Bustamante, Mariona

AU - Levy, Daniel

AU - London, Stephanie J.

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

AB - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

KW - cigarette smoking

KW - epigenetics

KW - infant

KW - maternal exposure

KW - methylation

U2 - 10.2217/epi-2019-0066

DO - 10.2217/epi-2019-0066

M3 - Article

VL - 11

SP - 1487

EP - 1500

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 13

ER -