Comparison of human health risks resulting from exposure to fungicides and mycotoxins via food

S.D. Muri, H. van der Voet, P.E. Boon, J.D. van Klaveren, B. Bruschweiler

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Scopus)


The interest in holistic considerations in the area of food safety is increasing. Risk managers may face the problem that reducing the risk of one compound may increase the risk of another compound. An example is the potential increase in mycotoxin levels due to a reduced use of fungicides in crop production. The Integrated Probabilistic Risk Assessment (IPRA) model was used to compare the estimated health impacts on humans caused by crops contaminated with the fungicides spiroxamine (SPI) and tebuconazole (TEB) or with the mycotoxins deoxynivalenol (DON) and zearalenone (ZEA). The IPRA model integrates a distribution characterising the exposure of individuals with a distribution characterising the susceptibility of individuals towards toxic effects. Its outcome, a distribution of Individual Margins of Exposure (IMoE), served as basis to perform comparisons of compounds, effects, countries, and population groups. Based on the available data and the assumptions made, none of the four compounds was found to have impact on human health in the addressed scenarios. The IMoE distributions were located as follows: DON <TEB = ZEA <SPI, showing DON to be the compound with the highest potential for negative health impacts. The presented approach can help risk managers to prioritise risk-reduction measures.
Original languageEnglish
Pages (from-to)2963-2974
JournalFood and Chemical Toxicology
Issue number12
Publication statusPublished - 2009


  • hazard characterization
  • deoxynivalenol
  • zearalenone
  • limits
  • mice

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