Comparison of hepatitis e virus sequences from humans and swine, the Netherlands, 1998–2015

Boris M. Hogema, Renate W. Hakze-Van der Honing*, Michel Molier, Hans L. Zaaijer, Wim H.M. van der Poel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

3 Citations (Scopus)


Pigs are suspected to be a major source of zoonotic hepatitis E virus (HEV) infection in industrialized countries, but the transmission route(s) from pigs to humans are ill-defined. Sequence comparison of HEV isolates from pigs with those from blood donors and patients in 372 samples collected in the Netherlands in 1998 and 1999 and between 2008 and 2015 showed that all sequences were genotype 3 except for six patients (with travel history). Subgenotype 3c (gt3c) was the most common subtype. While the proportion of gt3c increased significantly between 1998 and 2008, it remained constant between 2008 and 2015. Among the few circulating HEV subtypes, there was no difference observed between the human and the pig isolates. Hepatitis E viruses in humans are very likely to originate from pigs, but it is unclear why HEV gt3c has become the predominant subtype in the Netherlands.

Original languageEnglish
Article number1265
Issue number7
Publication statusPublished - 29 Jun 2021


  • Hepatitis E
  • Phylogenetic analysis
  • Zoonotic infection


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