Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12

D.G.J. Jennen; R.P.M.A. Crooijmans; B. Kamps; R. Acar; J.J. van der Poel; M.A.M. Groenen

doi:10.1007/s00335-003-3007-z

Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12

D.G.J. Jennen, R.P.M.A. Crooijmans, B. Kamps, R. Acar, J.J. van der Poel, M.A.M. Groenen

Research output: Contribution to journal › Article › Academic › peer-review

13 Citations (Scopus)

Abstract

The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.

Original language	English
Pages (from-to)	629-639
Journal	Mammalian Genome
Volume	14
Issue number	9
DOIs	https://doi.org/10.1007/s00335-003-3007-z
Publication status	Published - 2003

Keywords

genome rearrangements
mouse chromosome-5
linkage map
genes
human-chromosome-22
evolution

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title = "Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12",

abstract = "The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.",

keywords = "genome rearrangements, mouse chromosome-5, linkage map, genes, human-chromosome-22, evolution",

author = "D.G.J. Jennen and R.P.M.A. Crooijmans and B. Kamps and R. Acar and {van der Poel}, J.J. and M.A.M. Groenen",

year = "2003",

doi = "10.1007/s00335-003-3007-z",

language = "English",

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pages = "629--639",

journal = "Mammalian Genome",

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T1 - Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12

AU - Jennen, D.G.J.

AU - Crooijmans, R.P.M.A.

AU - Kamps, B.

AU - Acar, R.

AU - van der Poel, J.J.

AU - Groenen, M.A.M.

PY - 2003

Y1 - 2003

N2 - The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.

AB - The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.

KW - genome rearrangements

KW - mouse chromosome-5

KW - linkage map

KW - genes

KW - human-chromosome-22

KW - evolution

U2 - 10.1007/s00335-003-3007-z

DO - 10.1007/s00335-003-3007-z

M3 - Article

SN - 0938-8990

VL - 14

SP - 629

EP - 639

JO - Mammalian Genome

JF - Mammalian Genome

IS - 9

ER -

Comparative map between chicken chromosome 15 and human chromosomal region 12q24 and 22q11-q12

Abstract

Keywords

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