Community-level impacts of spatial repellents for control of diseases vectored by Aedes aegypti mosquitoes

Quirine A. ten Bosch*, Joseph M. Wagman, Fanny Castro-Llanos, Nicole L. Achee, John P. Grieco, T.A. Perkins

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Spatial repellents (SRs) reduce human-mosquito contact by preventing mosquito entrance into human-occupied spaces and interfering with host-seeking and blood-feeding. A new model to synthesize experimental data on the effects of transfluthrin on Aedes aegypti explores how SR effects interact to impact the epidemiology of diseases vectored by these mosquitoes. Our results indicate that the greatest impact on force of infection is expected to derive from the chemical's lethal effect but delayed biting and the negative effect this may have on the mosquito population could elicit substantial impact in the absence of lethality. The relative contributions of these effects depend on coverage, chemical dose, and housing density. We also demonstrate that, through an increase in the number of potentially mosquito bites, increased partial blood-feeding and reduced exiting may elicit adverse impacts, which could offset gains achieved by other effects. Our analysis demonstrates how small-scale experimental data can be leveraged to derive expectations of epidemiological impact of SRs deployed at larger scales.

Original languageEnglish
Article number1008190
JournalPLoS Computational Biology
Issue number9
Publication statusPublished - Sep 2020
Externally publishedYes

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