TY - JOUR
T1 - Community-level impacts of spatial repellents for control of diseases vectored by Aedes aegypti mosquitoes
AU - ten Bosch, Quirine A.
AU - Wagman, Joseph M.
AU - Castro-Llanos, Fanny
AU - Achee, Nicole L.
AU - Grieco, John P.
AU - Perkins, T.A.
PY - 2020/9
Y1 - 2020/9
N2 - Spatial repellents (SRs) reduce human-mosquito contact by preventing mosquito entrance into human-occupied spaces and interfering with host-seeking and blood-feeding. A new model to synthesize experimental data on the effects of transfluthrin on Aedes aegypti explores how SR effects interact to impact the epidemiology of diseases vectored by these mosquitoes. Our results indicate that the greatest impact on force of infection is expected to derive from the chemical's lethal effect but delayed biting and the negative effect this may have on the mosquito population could elicit substantial impact in the absence of lethality. The relative contributions of these effects depend on coverage, chemical dose, and housing density. We also demonstrate that, through an increase in the number of potentially mosquito bites, increased partial blood-feeding and reduced exiting may elicit adverse impacts, which could offset gains achieved by other effects. Our analysis demonstrates how small-scale experimental data can be leveraged to derive expectations of epidemiological impact of SRs deployed at larger scales.
AB - Spatial repellents (SRs) reduce human-mosquito contact by preventing mosquito entrance into human-occupied spaces and interfering with host-seeking and blood-feeding. A new model to synthesize experimental data on the effects of transfluthrin on Aedes aegypti explores how SR effects interact to impact the epidemiology of diseases vectored by these mosquitoes. Our results indicate that the greatest impact on force of infection is expected to derive from the chemical's lethal effect but delayed biting and the negative effect this may have on the mosquito population could elicit substantial impact in the absence of lethality. The relative contributions of these effects depend on coverage, chemical dose, and housing density. We also demonstrate that, through an increase in the number of potentially mosquito bites, increased partial blood-feeding and reduced exiting may elicit adverse impacts, which could offset gains achieved by other effects. Our analysis demonstrates how small-scale experimental data can be leveraged to derive expectations of epidemiological impact of SRs deployed at larger scales.
U2 - 10.1371/journal.pcbi.1008190
DO - 10.1371/journal.pcbi.1008190
M3 - Article
C2 - 32976489
AN - SCOPUS:85092232360
SN - 1553-734X
VL - 16
JO - PLoS Computational Biology
JF - PLoS Computational Biology
IS - 9
M1 - 1008190
ER -