TY - JOUR
T1 - Comment on “Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities”
AU - van Zadelhoff, Annemiek
AU - de Bruijn, Wouter J.C.
AU - Vincken, Jean Paul
PY - 2024/3/27
Y1 - 2024/3/27
N2 - This Comment critically addresses the article by Gao et al. ( Gao, K. , et al. J. Agric. Food Chem. 2015, 63, 1067−1075 ), providing the structural elucidation of three phenolamide dimers (neolignanamides) from the fruits of Lycium barbarum. A more recent article published by Chen et al. ( Chen, H. , et al. J. Agric. Food Chem. 2023, 71, 11080−11093 ) incorporates these structures into further research on the bioactivity of these compounds. Although the analytical techniques used by Gao et al. are adequate, in our opinion, the nuclear magnetic resonance (NMR) spectroscopic data have not been interpreted correctly, resulting in incorrect structures for three neolignanamides from the fruits of L. barbarum. In this Comment, an alternative interpretation of the NMR spectroscopic data and the corresponding structures are proposed. The proposed structures feature linkage types that are much more common for neolignanamides than the linkage types in the originally reported structures of these compounds.
AB - This Comment critically addresses the article by Gao et al. ( Gao, K. , et al. J. Agric. Food Chem. 2015, 63, 1067−1075 ), providing the structural elucidation of three phenolamide dimers (neolignanamides) from the fruits of Lycium barbarum. A more recent article published by Chen et al. ( Chen, H. , et al. J. Agric. Food Chem. 2023, 71, 11080−11093 ) incorporates these structures into further research on the bioactivity of these compounds. Although the analytical techniques used by Gao et al. are adequate, in our opinion, the nuclear magnetic resonance (NMR) spectroscopic data have not been interpreted correctly, resulting in incorrect structures for three neolignanamides from the fruits of L. barbarum. In this Comment, an alternative interpretation of the NMR spectroscopic data and the corresponding structures are proposed. The proposed structures feature linkage types that are much more common for neolignanamides than the linkage types in the originally reported structures of these compounds.
U2 - 10.1021/acs.jafc.3c08738
DO - 10.1021/acs.jafc.3c08738
M3 - Comment/Letter to the editor
C2 - 38470138
AN - SCOPUS:85187941620
SN - 0021-8561
VL - 72
SP - 6781
EP - 6786
JO - Journal of Agricultural and Food Chemistry
JF - Journal of Agricultural and Food Chemistry
IS - 12
ER -