Comment on “Three New Dimers and Two Monomers of Phenolic Amides from the Fruits of Lycium barbarum and Their Antioxidant Activities”

Annemiek van Zadelhoff, Wouter J.C. de Bruijn, Jean Paul Vincken*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademic

Abstract

This Comment critically addresses the article by Gao et al. ( Gao, K. , et al. J. Agric. Food Chem. 2015, 63, 1067−1075 ), providing the structural elucidation of three phenolamide dimers (neolignanamides) from the fruits of Lycium barbarum. A more recent article published by Chen et al. ( Chen, H. , et al. J. Agric. Food Chem. 2023, 71, 11080−11093 ) incorporates these structures into further research on the bioactivity of these compounds. Although the analytical techniques used by Gao et al. are adequate, in our opinion, the nuclear magnetic resonance (NMR) spectroscopic data have not been interpreted correctly, resulting in incorrect structures for three neolignanamides from the fruits of L. barbarum. In this Comment, an alternative interpretation of the NMR spectroscopic data and the corresponding structures are proposed. The proposed structures feature linkage types that are much more common for neolignanamides than the linkage types in the originally reported structures of these compounds.

Original languageEnglish
Pages (from-to)6781-6786
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume72
Issue number12
DOIs
Publication statusPublished - 27 Mar 2024

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