Combining Genomics and Metabolomics for the Discovery of Regulatory Genes and Their Use in Metabolic Engineering to Produce ‘Healthy Foods’

C. Martin, J. Luo, B. Lebouteiller, H.P. Mock, A. Matros, S. Peterek, E.G.W.M. Schijlen, R.D. Hall, L. Shintu, I. Colquhoun, B. Weisshaar, E. Butelli

Research output: Chapter in Book/Report/Conference proceedingConference paperAcademic

3 Citations (Scopus)

Abstract

Plants often accumulate their natural products to relatively low levels, so there is a lot of interest in breeding or engineering plants that produce higher levels. It has been shown that the most effective way to increase the accumulation of secondary metabolites is to increase the activity of genes that regulate the activity of the biosynthetic pathways that make different natural products. Regulatory genes of this type encode proteins called transcription factors. The biggest bottleneck in using this strategy to develop plants that accumulate significantly higher levels of important natural products is that not many transcription factors regulating secondary metabolism have yet been identified at the molecular level. Genes encoding transcription factors can be identified from model plants with sequenced genomes. The ability of such genes to regulate metabolism can be assayed by examination of mutants (reverse genetics) and by investigating the metabolic effects of high levels of expression of the genes. The combined techniques of metabolic fingerprinting and metabolite profiling of mutant and transgenic plants are allowing us to identify new genes encoding transcription factors controlling secondary metabolism, that can be used as tools for engineering natural product accumulation
Original languageEnglish
Title of host publicationProceedings of the I International Symposium on Genetic Modifications - Challenges and Opportunities for Horticulture in the World, Ski, Norway, 2011
EditorsA.K. Hvoslef-Eide
PublisherISHS
Pages73-84
ISBN (Print)9789066056541
DOIs
Publication statusPublished - 2012
EventI International Symposium on Genetic Modifications - Challenges and Opportunities for Horticulture in the World, Ski, Norway -
Duration: 16 Sep 200720 Sep 2007

Publication series

NameActa Horticulturae
Volume941
ISSN (Print)0567-7572

Conference

ConferenceI International Symposium on Genetic Modifications - Challenges and Opportunities for Horticulture in the World, Ski, Norway
Period16/09/0720/09/07

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