Combinations of Spok genes create multiple meiotic drivers in Podospora

Aaron A. Vogan, S.L. Ament-Velásquez, Alexandra Granger-Farbos, Jesper Svedberg, Eric Bastiaans, Alfons J.M. Debets, Virginie Coustou, Hélène Yvanne, Corinne Clavé, Sven J. Saupe, Hanna Johannesson*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

19 Citations (Scopus)

Abstract

Meiotic drive is the preferential transmission of a particular allele during sexual reproduction. The phenomenon is observed as spore killing in multiple fungi. In natural populations of Podospora anserina, seven spore killer types (Psks) have been identified through classical genetic analyses. Here we show that the Spok gene family underlies the Psks. The combination of Spok genes at different chromosomal locations defines the spore killer types and creates a killing hierarchy within a population. We identify two novel Spok homologs located within a large (74-167 kbp) region (the Spok block) that resides in different chromosomal locations in different strains. We confirm that the SPOK protein performs both killing and resistance functions and show that these activities are dependent on distinct domains, a predicted nuclease and kinase domain. Genomic and phylogenetic analyses across ascomycetes suggest that the Spok genes disperse through cross-species transfer, and evolve by duplication and diversification within lineages.

Original languageEnglish
JournaleLife
Volume8
DOIs
Publication statusPublished - 26 Jul 2019

Keywords

  • evolutionary biology
  • fungi
  • gene drive
  • genetics
  • genomic conflict
  • genomics
  • Podospora
  • selfish genetic element
  • spore killer

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