Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

A. Santoro, E. Pini, M. Scurti, G. Palmas, A.M. Berendsen, A.M. Brzozowska, C.P.G.M. de Groot, E.J.M. Feskens, W.M. de Vos

Research output: Contribution to journalArticleAcademicpeer-review

84 Citations (Scopus)

Abstract

The development of a chronic, low grade, inflammatory status named “inflammaging” is a major characteristic of ageing, which plays a critical role in the pathogenesis of age-related diseases. Inflammaging is both local and systemic, and a variety of organs and systems contribute inflammatory stimuli that accumulate lifelong. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65–79 years of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics and metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and ageing, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.
Original languageEnglish
Pages (from-to)3-13
JournalMechanisms of Ageing and Development
Volume136-137
DOIs
Publication statusPublished - 2014

Keywords

  • cd8(+) t-cells
  • style diet
  • cellular senescence
  • older-adults
  • longevity
  • immunosenescence
  • phenotype
  • frailty
  • system
  • muscle

Fingerprint Dive into the research topics of 'Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design'. Together they form a unique fingerprint.

Cite this