Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale

A. Santoro, E. Pini, M. Scurti, G. Palmas, A. Berendsen, A.M. Brzozowska, A. The NU-AGE Consortium, C.P.G.M. de Groot, E.J.M. Feskens, S. Fairweather-Tait, S. Salvioli, M. Capri

Research output: Contribution to journalAbstractAcademic

Abstract

The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of aging which plays a critical role in the pathogenesis of age-related diseases. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 year of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics, metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and aging, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.
Original languageEnglish
Pages (from-to)S3-S4
JournalFree Radical Biology and Medicine
Volume65
Issue numberSuppl. 1
DOIs
Publication statusPublished - 2013

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Mediterranean Diet
Nutrition
Metagenomics
Food
Metabolomics
Systems Biology
United Nations
Food Industry
Aging of materials
Administrative Personnel
Epigenomics
Health Status
Industry
Databases
Research
Health

Cite this

Santoro, A., Pini, E., Scurti, M., Palmas, G., Berendsen, A., Brzozowska, A. M., ... Capri, M. (2013). Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale. Free Radical Biology and Medicine, 65(Suppl. 1), S3-S4. https://doi.org/10.1016/j.freeradbiomed.2013.08.109
Santoro, A. ; Pini, E. ; Scurti, M. ; Palmas, G. ; Berendsen, A. ; Brzozowska, A.M. ; The NU-AGE Consortium, A. ; de Groot, C.P.G.M. ; Feskens, E.J.M. ; Fairweather-Tait, S. ; Salvioli, S. ; Capri, M. / Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale. In: Free Radical Biology and Medicine. 2013 ; Vol. 65, No. Suppl. 1. pp. S3-S4.
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abstract = "The development of a chronic, low grade, inflammatory status named {"}inflammaging{"} is a major characteristic of aging which plays a critical role in the pathogenesis of age-related diseases. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 year of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics, metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and aging, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.",
author = "A. Santoro and E. Pini and M. Scurti and G. Palmas and A. Berendsen and A.M. Brzozowska and {The NU-AGE Consortium}, A. and {de Groot}, C.P.G.M. and E.J.M. Feskens and S. Fairweather-Tait and S. Salvioli and M. Capri",
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Santoro, A, Pini, E, Scurti, M, Palmas, G, Berendsen, A, Brzozowska, AM, The NU-AGE Consortium, A, de Groot, CPGM, Feskens, EJM, Fairweather-Tait, S, Salvioli, S & Capri, M 2013, 'Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale', Free Radical Biology and Medicine, vol. 65, no. Suppl. 1, pp. S3-S4. https://doi.org/10.1016/j.freeradbiomed.2013.08.109

Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale. / Santoro, A.; Pini, E.; Scurti, M.; Palmas, G.; Berendsen, A.; Brzozowska, A.M.; The NU-AGE Consortium, A.; de Groot, C.P.G.M.; Feskens, E.J.M.; Fairweather-Tait, S.; Salvioli, S.; Capri, M.

In: Free Radical Biology and Medicine, Vol. 65, No. Suppl. 1, 2013, p. S3-S4.

Research output: Contribution to journalAbstractAcademic

TY - JOUR

T1 - Combating 'inflammaging' through a Mediterranean whole diet approach: the NU-AGE project rationale

AU - Santoro, A.

AU - Pini, E.

AU - Scurti, M.

AU - Palmas, G.

AU - Berendsen, A.

AU - Brzozowska, A.M.

AU - The NU-AGE Consortium, A.

AU - de Groot, C.P.G.M.

AU - Feskens, E.J.M.

AU - Fairweather-Tait, S.

AU - Salvioli, S.

AU - Capri, M.

PY - 2013

Y1 - 2013

N2 - The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of aging which plays a critical role in the pathogenesis of age-related diseases. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 year of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics, metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and aging, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

AB - The development of a chronic, low grade, inflammatory status named "inflammaging" is a major characteristic of aging which plays a critical role in the pathogenesis of age-related diseases. The NU-AGE rationale is that a one year Mediterranean whole diet (considered by UNESCO a heritage of humanity), newly designed to meet the nutritional needs of the elderly, will reduce inflammaging in fully characterized subjects aged 65-79 year of age, and will have systemic beneficial effects on health status (physical and cognitive). Before and after the dietary intervention a comprehensive set of analyses, including omics (transcriptomics, epigenetics, metabolomics, metagenomics) will be performed to identify the underpinning molecular mechanisms. NU-AGE will set up a comprehensive database as a tool for a systems biology approach to inflammaging and nutrition. NU-AGE is highly interdisciplinary, includes leading research centres in Europe on nutrition and aging, and is complemented by EU multinational food industries and SMEs, interested in the production of functional and enriched/advanced traditional food tailored for the elderly market, and European Federations targeting policy makers and major stakeholders, from consumers to EU Food & Drink Industries.

U2 - 10.1016/j.freeradbiomed.2013.08.109

DO - 10.1016/j.freeradbiomed.2013.08.109

M3 - Abstract

VL - 65

SP - S3-S4

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

SN - 0891-5849

IS - Suppl. 1

ER -