Cold acclimation with shivering improves metabolic health in adults with overweight or obesity

Adam J. Sellers; Sten M.M. van Beek; Dzhansel Hashim; Rosalie Baak; Hannah Pallubinsky; Esther Moonen-Kornips; Gert Schaart; Anne Gemmink; Johanna A. Jörgensen; Tineke van de Weijer; Eric Kalkhoven; Guido J. Hooiveld; Sander Kersten; Matthijs K.C. Hesselink; Patrick Schrauwen; Joris Hoeks; Wouter D. van Marken Lichtenbelt

doi:10.1038/s42255-024-01172-y

Cold acclimation with shivering improves metabolic health in adults with overweight or obesity

Adam J. Sellers, Sten M.M. van Beek, Dzhansel Hashim, Rosalie Baak, Hannah Pallubinsky, Esther Moonen-Kornips, Gert Schaart, Anne Gemmink, Johanna A. Jörgensen, Tineke van de Weijer, Eric Kalkhoven, Guido J. Hooiveld, Sander Kersten, Matthijs K.C. Hesselink, Patrick Schrauwen, Joris Hoeks^*, Wouter D. van Marken Lichtenbelt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

4 Citations (Scopus)

Abstract

Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.

Original language	English
Article number	1516
Pages (from-to)	2246-2253
Number of pages	8
Journal	Nature Metabolism
Volume	6
DOIs	https://doi.org/10.1038/s42255-024-01172-y
Publication status	Published - 6 Dec 2024

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10.1038/s42255-024-01172-y

Shivering improves metabolic health in adults with overweight or obesity
Sellers, A. J. (Creator), van Beek, S. M. M. (Creator), Hashim, D. (Creator), Baak, R. (Creator), Pallubinsky, H. (Creator), Moonen-Kornips, E. (Creator), Schaart, G. (Creator), Gemmink, A. (Creator), Jörgensen, J. A. (Creator), van de Weijer, T. (Creator), Kalkhoven, E. (Creator), Hooiveld, G. J. (Creator), Kersten, S. (Creator), Hesselink, M. K. C. (Creator), Schrauwen, P. (Creator), Hoeks, J. (Creator) & van Marken Lichtenbelt, W. D. (Creator), Wageningen University & Research, 3 Jul 2024
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE271452
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Sellers, A. J., van Beek, S. M. M., Hashim, D., Baak, R., Pallubinsky, H., Moonen-Kornips, E., Schaart, G., Gemmink, A., Jörgensen, J. A., van de Weijer, T., Kalkhoven, E., Hooiveld, G. J., Kersten, S., Hesselink, M. K. C., Schrauwen, P., Hoeks, J., & van Marken Lichtenbelt, W. D. (2024). Cold acclimation with shivering improves metabolic health in adults with overweight or obesity. Nature Metabolism, 6, 2246-2253. Article 1516. https://doi.org/10.1038/s42255-024-01172-y

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title = "Cold acclimation with shivering improves metabolic health in adults with overweight or obesity",

abstract = "Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.",

author = "Sellers, {Adam J.} and {van Beek}, {Sten M.M.} and Dzhansel Hashim and Rosalie Baak and Hannah Pallubinsky and Esther Moonen-Kornips and Gert Schaart and Anne Gemmink and J{\"o}rgensen, {Johanna A.} and {van de Weijer}, Tineke and Eric Kalkhoven and Hooiveld, {Guido J.} and Sander Kersten and Hesselink, {Matthijs K.C.} and Patrick Schrauwen and Joris Hoeks and {van Marken Lichtenbelt}, {Wouter D.}",

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Sellers, AJ, van Beek, SMM, Hashim, D, Baak, R, Pallubinsky, H, Moonen-Kornips, E, Schaart, G, Gemmink, A, Jörgensen, JA, van de Weijer, T, Kalkhoven, E, Hooiveld, GJ , Kersten, S, Hesselink, MKC, Schrauwen, P, Hoeks, J & van Marken Lichtenbelt, WD 2024, 'Cold acclimation with shivering improves metabolic health in adults with overweight or obesity', Nature Metabolism, vol. 6, 1516, pp. 2246-2253. https://doi.org/10.1038/s42255-024-01172-y

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T1 - Cold acclimation with shivering improves metabolic health in adults with overweight or obesity

AU - Sellers, Adam J.

AU - van Beek, Sten M.M.

AU - Hashim, Dzhansel

AU - Baak, Rosalie

AU - Pallubinsky, Hannah

AU - Moonen-Kornips, Esther

AU - Schaart, Gert

AU - Gemmink, Anne

AU - Jörgensen, Johanna A.

AU - van de Weijer, Tineke

AU - Kalkhoven, Eric

AU - Hooiveld, Guido J.

AU - Kersten, Sander

AU - Hesselink, Matthijs K.C.

AU - Schrauwen, Patrick

AU - Hoeks, Joris

AU - van Marken Lichtenbelt, Wouter D.

PY - 2024/12/6

Y1 - 2024/12/6

N2 - Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.

AB - Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.

U2 - 10.1038/s42255-024-01172-y

DO - 10.1038/s42255-024-01172-y

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AN - SCOPUS:85211629186

SN - 2522-5812

VL - 6

SP - 2246

EP - 2253

JO - Nature Metabolism

JF - Nature Metabolism

M1 - 1516

ER -

Cold acclimation with shivering improves metabolic health in adults with overweight or obesity

Abstract

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Shivering improves metabolic health in adults with overweight or obesity

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