TY - JOUR
T1 - Cold acclimation with shivering improves metabolic health in adults with overweight or obesity
AU - Sellers, Adam J.
AU - van Beek, Sten M.M.
AU - Hashim, Dzhansel
AU - Baak, Rosalie
AU - Pallubinsky, Hannah
AU - Moonen-Kornips, Esther
AU - Schaart, Gert
AU - Gemmink, Anne
AU - Jörgensen, Johanna A.
AU - van de Weijer, Tineke
AU - Kalkhoven, Eric
AU - Hooiveld, Guido J.
AU - Kersten, Sander
AU - Hesselink, Matthijs K.C.
AU - Schrauwen, Patrick
AU - Hoeks, Joris
AU - van Marken Lichtenbelt, Wouter D.
PY - 2024/12/6
Y1 - 2024/12/6
N2 - Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.
AB - Cold acclimation increases insulin sensitivity, and some level of muscle contraction appears to be needed for provoking this effect. Here 15 men and (postmenopausal) women with overweight or obesity, the majority of whom had impaired glucose tolerance, were intermittently exposed to cold to induce 1 h of shivering per day over 10 days. We determined the effect of cold acclimation with shivering on overnight fasted oral glucose tolerance (primary outcome) and on skeletal muscle glucose transporter 4 translocation (secondary outcome). We find that cold acclimation with shivering improves oral glucose tolerance, fasting glucose, triglycerides, non-esterified fatty acid concentrations and blood pressure. Cold acclimation with shivering may thus represent an alternative lifestyle approach for the prevention and treatment of obesity-related metabolic disorders. ClinicalTrials.gov registration: NCT04516018.
U2 - 10.1038/s42255-024-01172-y
DO - 10.1038/s42255-024-01172-y
M3 - Article
AN - SCOPUS:85211629186
SN - 2522-5812
VL - 6
SP - 2246
EP - 2253
JO - Nature Metabolism
JF - Nature Metabolism
M1 - 1516
ER -