TY - JOUR
T1 - Cohort profile
T2 - Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO)
AU - Loo, Evelyn Xiu Ling
AU - Soh, Shu E.
AU - Loy, See Ling
AU - Ng, Sharon
AU - Tint, Mya Thway
AU - Chan, Shiao Yng
AU - Huang, Jonathan Yinhao
AU - Yap, Fabian
AU - Tan, Kok Hian
AU - Chern, Bernard S.M.
AU - Tan, Heng Hao
AU - Meaney, Michael J.
AU - Karnani, Neerja
AU - Godfrey, Keith M.
AU - Lee, Yung Seng
AU - Chan, Jerry Kok Yen
AU - Gluckman, Peter D.
AU - Chong, Yap Seng
AU - Shek, Lynette Pei Chi
AU - Eriksson, Johan G.
AU - Chia, Airu
AU - Fogel, Anna Magdalena
AU - Goh, Anne Eng Neo
AU - Chu, Anne Hin Yee
AU - Rifkin-Graboi, Anne
AU - Qiu, Anqi
AU - Lee, Bee Wah
AU - Cheon, Bobby Kyungbeom
AU - Vaz, Candida
AU - Henry, Christiani Jeyakumar
AU - Forde, Ciaran Gerard
AU - Chi, Claudia
AU - Koh, Dawn Xin Ping
AU - Phua, Desiree Y.
AU - Loh, Doris Ngiuk Lan
AU - Quah, Elaine Phaik Ling
AU - Tham, Elizabeth Huiwen
AU - Law, Evelyn Chung Ning
AU - Magkos, Faidon
AU - Mueller-Riemenschneider, Falk
AU - Yeo, George Seow Heong
AU - Yong, Hannah Ee Juen
AU - Chen, Helen Yu
AU - Pan, Hong
AU - van Bever, Hugo P.S.
AU - Tan, Hui Min
AU - Aris, Izzuddin Bin Mohd
AU - Tay, Jeannie
AU - Xu, Jia
AU - Yoong, Joanne Su Yin
PY - 2021/1
Y1 - 2021/1
N2 - The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6–8, 11–13, 18–21, 24–26, 27–28 and 34–36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother–offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.
AB - The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outcomes including duration of gestation, fetal growth, metabolic and neural phenotypes in the offspring. Between February 2015 and October 2017, the S-PRESTO study recruited 1039 Chinese, Malay or Indian (or any combinations thereof) women aged 18–45 years and who intended to get pregnant and deliver in Singapore, resulting in 1032 unique participants and 373 children born in the cohort. The participants were followed up for 3 visits during the preconception phase and censored at 12 months of follow up if pregnancy was not achieved (N = 557 censored). Women who successfully conceived (N = 475) were characterised at gestational weeks 6–8, 11–13, 18–21, 24–26, 27–28 and 34–36. Follow up of their index offspring (N = 373 singletons) is on-going at birth, 1, 3 and 6 weeks, 3, 6, 12, 18, 24 and 36 months and beyond. Women are also being followed up post-delivery. Data is collected via interviewer-administered questionnaires, metabolic imaging (magnetic resonance imaging), standardized anthropometric measurements and collection of diverse specimens, i.e. blood, urine, buccal smear, stool, skin tapes, epithelial swabs at numerous timepoints. S-PRESTO has extensive repeated data collected which include genetic and epigenetic sampling from preconception which is unique in mother–offspring epidemiological cohorts. This enables prospective assessment of a wide array of potential determinants of future health outcomes in women from preconception to post-delivery and in their offspring across the earliest development from embryonic stages into early childhood. In addition, the S-PRESTO study draws from the three major Asian ethnic groups that represent 50% of the global population, increasing the relevance of its findings to global efforts to address non-communicable diseases.
U2 - 10.1007/s10654-020-00697-2
DO - 10.1007/s10654-020-00697-2
M3 - Article
AN - SCOPUS:85096582657
SN - 0393-2990
VL - 36
SP - 129
EP - 142
JO - European Journal of Epidemiology
JF - European Journal of Epidemiology
IS - 1
ER -
