TY - JOUR
T1 - Coffee Consumption and Coronary Calcification in Elderly People: The Rotterdam Coronary Calcification Study
AU - Geleijnse, J.M.
AU - van Woudenbergh, G.J.
AU - Vliegenthart, R.
AU - Witteman, J.C.
PY - 2008
Y1 - 2008
N2 - Background: Diet and lifestyle play an important role in the development of coronary heart
disease (CHD). The role of coffee in the cardiovascular system is not yet clear. We examined
whether coffee consumption was related to severe coronary calcification, a strong predictor for
CHD morbidity and mortality. Methods: The relation coffee consumption with coronary
calcification was examined in 1,570 elderly men and women without CHD who participated in
the Rotterdam Study. Habitual coffee use was assessed with a semiquantitative food frequency
questionnaire. Coronary calcification was detected with electron beam computed tomography.
Severe calcification was quantified as an Agatson calcium score >400. Sex-specific odds
ratios (ORs) with 95% confidence intervals (95% CI) were obtained by multivariable logistic
regression, adjusted for age, smoking, body mass index, education, and intake of energy and
alcohol. Results: In multivariable analysis, coronary calcification in women was significantly
inversely associated both with moderate (>3 to 4 cups) and high (>4 cups) coffee
consumption, compared with a daily intake of 3 cups or less (OR of 0.41 [95% CI: 0.25 to 0.65]
and 0.54 [0.33 to 0.87], respectively). The association persisted after additional adjustment
for intake of tea, fruit, meat, and saturated fat. No significant association was found in men.
Conclusion: Coffee was inversely associated with coronary calcification in women, whereas in
non-smoking men a direct association was observed. Further studies should clarify the role of
gender in the relation between coffee and coronary calcification
AB - Background: Diet and lifestyle play an important role in the development of coronary heart
disease (CHD). The role of coffee in the cardiovascular system is not yet clear. We examined
whether coffee consumption was related to severe coronary calcification, a strong predictor for
CHD morbidity and mortality. Methods: The relation coffee consumption with coronary
calcification was examined in 1,570 elderly men and women without CHD who participated in
the Rotterdam Study. Habitual coffee use was assessed with a semiquantitative food frequency
questionnaire. Coronary calcification was detected with electron beam computed tomography.
Severe calcification was quantified as an Agatson calcium score >400. Sex-specific odds
ratios (ORs) with 95% confidence intervals (95% CI) were obtained by multivariable logistic
regression, adjusted for age, smoking, body mass index, education, and intake of energy and
alcohol. Results: In multivariable analysis, coronary calcification in women was significantly
inversely associated both with moderate (>3 to 4 cups) and high (>4 cups) coffee
consumption, compared with a daily intake of 3 cups or less (OR of 0.41 [95% CI: 0.25 to 0.65]
and 0.54 [0.33 to 0.87], respectively). The association persisted after additional adjustment
for intake of tea, fruit, meat, and saturated fat. No significant association was found in men.
Conclusion: Coffee was inversely associated with coronary calcification in women, whereas in
non-smoking men a direct association was observed. Further studies should clarify the role of
gender in the relation between coffee and coronary calcification
M3 - Abstract
SN - 0009-7322
VL - 117
SP - e237, P130
JO - Circulation
JF - Circulation
IS - 11
ER -