Coffee Consumption and Coronary Calcification in Elderly People: The Rotterdam Coronary Calcification Study

J.M. Geleijnse, G.J. van Woudenbergh, R. Vliegenthart, J.C. Witteman

Research output: Contribution to journalAbstractAcademic


Background: Diet and lifestyle play an important role in the development of coronary heart disease (CHD). The role of coffee in the cardiovascular system is not yet clear. We examined whether coffee consumption was related to severe coronary calcification, a strong predictor for CHD morbidity and mortality. Methods: The relation coffee consumption with coronary calcification was examined in 1,570 elderly men and women without CHD who participated in the Rotterdam Study. Habitual coffee use was assessed with a semiquantitative food frequency questionnaire. Coronary calcification was detected with electron beam computed tomography. Severe calcification was quantified as an Agatson calcium score >400. Sex-specific odds ratios (ORs) with 95% confidence intervals (95% CI) were obtained by multivariable logistic regression, adjusted for age, smoking, body mass index, education, and intake of energy and alcohol. Results: In multivariable analysis, coronary calcification in women was significantly inversely associated both with moderate (>3 to 4 cups) and high (>4 cups) coffee consumption, compared with a daily intake of 3 cups or less (OR of 0.41 [95% CI: 0.25 to 0.65] and 0.54 [0.33 to 0.87], respectively). The association persisted after additional adjustment for intake of tea, fruit, meat, and saturated fat. No significant association was found in men. Conclusion: Coffee was inversely associated with coronary calcification in women, whereas in non-smoking men a direct association was observed. Further studies should clarify the role of gender in the relation between coffee and coronary calcification
Original languageEnglish
Pages (from-to)e237, P130
Issue number11
Publication statusPublished - 2008

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