TY - JOUR
T1 - Coevolution between bacterial CRISPR-Cas systems and their bacteriophages
AU - Watson, Bridget N.J.
AU - Steens, Jurre A.
AU - Staals, Raymond H.J.
AU - Westra, Edze R.
AU - van Houte, Stineke
PY - 2021/5/12
Y1 - 2021/5/12
N2 - CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity against their viruses (bacteriophages and phages) and other parasitic genetic elements. CRISPR-Cas systems are highly diverse, and we are only beginning to understand their relative importance in phage defense. In this review, we will discuss when and why CRISPR-Cas immunity against phages evolves, and how this, in turn, selects for the evolution of immune evasion by phages. Finally, we will discuss our current understanding of if, and when, we observe coevolution between CRISPR-Cas systems and phages, and how this may be influenced by the mechanism of CRISPR-Cas immunity.
AB - CRISPR-Cas systems provide bacteria and archaea with adaptive, heritable immunity against their viruses (bacteriophages and phages) and other parasitic genetic elements. CRISPR-Cas systems are highly diverse, and we are only beginning to understand their relative importance in phage defense. In this review, we will discuss when and why CRISPR-Cas immunity against phages evolves, and how this, in turn, selects for the evolution of immune evasion by phages. Finally, we will discuss our current understanding of if, and when, we observe coevolution between CRISPR-Cas systems and phages, and how this may be influenced by the mechanism of CRISPR-Cas immunity.
KW - bacteriophages
KW - coevolution
KW - CRISPR-Cas
KW - ecology
KW - evolution
U2 - 10.1016/j.chom.2021.03.018
DO - 10.1016/j.chom.2021.03.018
M3 - Article
AN - SCOPUS:85105524013
SN - 1931-3128
VL - 29
SP - 715
EP - 725
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 5
ER -