Co-current crossflow microfiltration in a microchannel

Levy I. Amar*, Michael I. Hill, Monica Faria, Daniela Guisado, Cees J.M. van Rijn, Edward F. Leonard

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Steady state crossflow microfiltration (CMF) is an important and often necessary means of particle separation and concentration for both industrial and biomedical processes. The factors controlling the performance of CMF have been extensively reviewed. A major factor is transmembrane pressure (TMP). Because microchannels have small height, they tend to have high pressure gradients in the feed-flow direction. In the extreme, these gradients may even reverse the pressure across the membrane (inciting backflow). It is therefore desirable to compensate for the effect of feed-flow on the TMP, aiming at constant transmembrane pressure (cTMP) at a value which maximizes filtrate flux. This is especially critical during filtration of deformable particles (e.g. erythrocytes) through low intrinsic resistance membranes. Filtration flux is generally taken to be directly proportional to TMP, with pressure drop along the channel decreasing in the flow direction. A co-current flow of filtrate in a suitably designed filtrate collecting channel is shown to allow the TMP to remain constant and permit the sieving surface to perform optimally, permitting up to twice as much filtration over that of a naïve configuration. Manipulation of the filtrate channel may be even more beneficial if it prevents backflow that might otherwise occur at the end of a sufficiently long channel. Experiments with erythrocyte suspensions, reported here, validate these concepts.

Original languageEnglish
Number of pages1
JournalBiomedical Microdevices
Volume21
Issue number1
DOIs
Publication statusPublished - 6 Feb 2019

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Microfiltration
Microchannels
Pressure
Fluxes
Membranes
Erythrocytes
Pressure gradient
Pressure drop
Suspensions
Experiments

Keywords

  • Blood
  • Constant transmembrane pressure
  • Cross-flow
  • Erythrocytes
  • Microfiltration model
  • Microfluidics
  • Microsieve
  • Nanopores
  • Plasma
  • Sieve

Cite this

Amar, Levy I. ; Hill, Michael I. ; Faria, Monica ; Guisado, Daniela ; van Rijn, Cees J.M. ; Leonard, Edward F. / Co-current crossflow microfiltration in a microchannel. In: Biomedical Microdevices. 2019 ; Vol. 21, No. 1.
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Co-current crossflow microfiltration in a microchannel. / Amar, Levy I.; Hill, Michael I.; Faria, Monica; Guisado, Daniela; van Rijn, Cees J.M.; Leonard, Edward F.

In: Biomedical Microdevices, Vol. 21, No. 1, 06.02.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Co-current crossflow microfiltration in a microchannel

AU - Amar, Levy I.

AU - Hill, Michael I.

AU - Faria, Monica

AU - Guisado, Daniela

AU - van Rijn, Cees J.M.

AU - Leonard, Edward F.

PY - 2019/2/6

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AB - Steady state crossflow microfiltration (CMF) is an important and often necessary means of particle separation and concentration for both industrial and biomedical processes. The factors controlling the performance of CMF have been extensively reviewed. A major factor is transmembrane pressure (TMP). Because microchannels have small height, they tend to have high pressure gradients in the feed-flow direction. In the extreme, these gradients may even reverse the pressure across the membrane (inciting backflow). It is therefore desirable to compensate for the effect of feed-flow on the TMP, aiming at constant transmembrane pressure (cTMP) at a value which maximizes filtrate flux. This is especially critical during filtration of deformable particles (e.g. erythrocytes) through low intrinsic resistance membranes. Filtration flux is generally taken to be directly proportional to TMP, with pressure drop along the channel decreasing in the flow direction. A co-current flow of filtrate in a suitably designed filtrate collecting channel is shown to allow the TMP to remain constant and permit the sieving surface to perform optimally, permitting up to twice as much filtration over that of a naïve configuration. Manipulation of the filtrate channel may be even more beneficial if it prevents backflow that might otherwise occur at the end of a sufficiently long channel. Experiments with erythrocyte suspensions, reported here, validate these concepts.

KW - Blood

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KW - Microsieve

KW - Nanopores

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