Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial

Anne Sophie Weyns; Annelies A.J. Verlaet; Annelies Breynaert; Tania Naessens; Erik Fransen; Helene Verhelst; Dirk Van West; Ingrid Van Ingelghem; An I. Jonckheere; Diane Beysen; Sandra Kenis; Els Moens; Aalt P.J. van Roest; Huub F.J. Savelkoul; Tess De Bruyne; Luc Pieters; Berten Ceulemans; Nina Hermans

doi:10.1016/j.jff.2022.105246

Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial

Anne Sophie Weyns^*, Annelies A.J. Verlaet, Annelies Breynaert, Tania Naessens, Erik Fransen, Helene Verhelst, Dirk Van West, Ingrid Van Ingelghem, An I. Jonckheere, Diane Beysen, Sandra Kenis, Els Moens, Aalt P.J. van Roest, Huub F.J. Savelkoul, Tess De Bruyne, Luc Pieters, Berten Ceulemans, Nina Hermans

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

5 Citations (Scopus)

Abstract

Objectives: Determine the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol®) on Attention-Deficit Hyperactivity Disorder (ADHD) behaviour and co-morbid physical/psychiatric symptoms, compared to placebo and the medicine MPH, and to assess its tolerability. Behaviour (measured by the ADHD-Rating Scale (ADHD-RS) and Social-Emotional Questionnaire (SEQ)) and physical complaints were evaluated in weeks 5 and 10. Results: Eighty-eight paediatric ADHD patients (70 % male, mean age 10.1 years) were randomised to placebo (n = 30), PBE (n = 32) or MPH (n = 26). Teachers reported significant improvement of total and hyperactivity/impulsivity ADHD-RS scores by PBE and MPH after 10 weeks compared to placebo. MPH also improved inattention. SEQ ratings support ADHD-RS results. Adverse effects were reported five times more frequently for MPH than for PBE. Conclusions: PBE appears a good alternative for MPH in paediatric ADHD and especially in the primary school environment, a fortiori when considering its almost complete lack of adverse effects.

Original language	English
Article number	105246
Journal	Journal of Functional Foods
Volume	97
DOIs	https://doi.org/10.1016/j.jff.2022.105246
Publication status	Published - Oct 2022

Keywords

ADHD
Antioxidant
Behaviour
French Maritime Pine Bark Extract
Methylphenidate
Polyphenols

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https://edepot.wur.nl/578883Licence: CC BY-NC-ND

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Weyns, A. S., Verlaet, A. A. J., Breynaert, A., Naessens, T., Fransen, E., Verhelst, H., Van West, D., Van Ingelghem, I., Jonckheere, A. I., Beysen, D., Kenis, S., Moens, E., van Roest, A. P. J., Savelkoul, H. F. J., De Bruyne, T., Pieters, L., Ceulemans, B., & Hermans, N. (2022). Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial. Journal of Functional Foods, 97, Article 105246. https://doi.org/10.1016/j.jff.2022.105246

@article{6d314bb335be4d6ea817ab2d9d314029,

title = "Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial",

abstract = "Objectives: Determine the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol{\textregistered}) on Attention-Deficit Hyperactivity Disorder (ADHD) behaviour and co-morbid physical/psychiatric symptoms, compared to placebo and the medicine MPH, and to assess its tolerability. Behaviour (measured by the ADHD-Rating Scale (ADHD-RS) and Social-Emotional Questionnaire (SEQ)) and physical complaints were evaluated in weeks 5 and 10. Results: Eighty-eight paediatric ADHD patients (70 % male, mean age 10.1 years) were randomised to placebo (n = 30), PBE (n = 32) or MPH (n = 26). Teachers reported significant improvement of total and hyperactivity/impulsivity ADHD-RS scores by PBE and MPH after 10 weeks compared to placebo. MPH also improved inattention. SEQ ratings support ADHD-RS results. Adverse effects were reported five times more frequently for MPH than for PBE. Conclusions: PBE appears a good alternative for MPH in paediatric ADHD and especially in the primary school environment, a fortiori when considering its almost complete lack of adverse effects.",

keywords = "ADHD, Antioxidant, Behaviour, French Maritime Pine Bark Extract, Methylphenidate, Polyphenols",

author = "Weyns, {Anne Sophie} and Verlaet, {Annelies A.J.} and Annelies Breynaert and Tania Naessens and Erik Fransen and Helene Verhelst and {Van West}, Dirk and {Van Ingelghem}, Ingrid and Jonckheere, {An I.} and Diane Beysen and Sandra Kenis and Els Moens and {van Roest}, {Aalt P.J.} and Savelkoul, {Huub F.J.} and {De Bruyne}, Tess and Luc Pieters and Berten Ceulemans and Nina Hermans",

year = "2022",

month = oct,

doi = "10.1016/j.jff.2022.105246",

language = "English",

volume = "97",

journal = "Journal of Functional Foods",

issn = "1756-4646",

publisher = "Elsevier",

}

Weyns, AS, Verlaet, AAJ, Breynaert, A, Naessens, T, Fransen, E, Verhelst, H, Van West, D, Van Ingelghem, I, Jonckheere, AI, Beysen, D, Kenis, S, Moens, E, van Roest, APJ, Savelkoul, HFJ, De Bruyne, T, Pieters, L, Ceulemans, B & Hermans, N 2022, 'Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial', Journal of Functional Foods, vol. 97, 105246. https://doi.org/10.1016/j.jff.2022.105246

Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial. / Weyns, Anne Sophie; Verlaet, Annelies A.J.; Breynaert, Annelies et al.
In: Journal of Functional Foods, Vol. 97, 105246, 10.2022.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo

T2 - Part 1: Efficacy in a Randomised Trial

AU - Weyns, Anne Sophie

AU - Verlaet, Annelies A.J.

AU - Breynaert, Annelies

AU - Naessens, Tania

AU - Fransen, Erik

AU - Verhelst, Helene

AU - Van West, Dirk

AU - Van Ingelghem, Ingrid

AU - Jonckheere, An I.

AU - Beysen, Diane

AU - Kenis, Sandra

AU - Moens, Els

AU - van Roest, Aalt P.J.

AU - Savelkoul, Huub F.J.

AU - De Bruyne, Tess

AU - Pieters, Luc

AU - Ceulemans, Berten

AU - Hermans, Nina

PY - 2022/10

Y1 - 2022/10

N2 - Objectives: Determine the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol®) on Attention-Deficit Hyperactivity Disorder (ADHD) behaviour and co-morbid physical/psychiatric symptoms, compared to placebo and the medicine MPH, and to assess its tolerability. Behaviour (measured by the ADHD-Rating Scale (ADHD-RS) and Social-Emotional Questionnaire (SEQ)) and physical complaints were evaluated in weeks 5 and 10. Results: Eighty-eight paediatric ADHD patients (70 % male, mean age 10.1 years) were randomised to placebo (n = 30), PBE (n = 32) or MPH (n = 26). Teachers reported significant improvement of total and hyperactivity/impulsivity ADHD-RS scores by PBE and MPH after 10 weeks compared to placebo. MPH also improved inattention. SEQ ratings support ADHD-RS results. Adverse effects were reported five times more frequently for MPH than for PBE. Conclusions: PBE appears a good alternative for MPH in paediatric ADHD and especially in the primary school environment, a fortiori when considering its almost complete lack of adverse effects.

AB - Objectives: Determine the effect of French Maritime Pine Bark Extract (PBE; Pycnogenol®) on Attention-Deficit Hyperactivity Disorder (ADHD) behaviour and co-morbid physical/psychiatric symptoms, compared to placebo and the medicine MPH, and to assess its tolerability. Behaviour (measured by the ADHD-Rating Scale (ADHD-RS) and Social-Emotional Questionnaire (SEQ)) and physical complaints were evaluated in weeks 5 and 10. Results: Eighty-eight paediatric ADHD patients (70 % male, mean age 10.1 years) were randomised to placebo (n = 30), PBE (n = 32) or MPH (n = 26). Teachers reported significant improvement of total and hyperactivity/impulsivity ADHD-RS scores by PBE and MPH after 10 weeks compared to placebo. MPH also improved inattention. SEQ ratings support ADHD-RS results. Adverse effects were reported five times more frequently for MPH than for PBE. Conclusions: PBE appears a good alternative for MPH in paediatric ADHD and especially in the primary school environment, a fortiori when considering its almost complete lack of adverse effects.

KW - ADHD

KW - Antioxidant

KW - Behaviour

KW - French Maritime Pine Bark Extract

KW - Methylphenidate

KW - Polyphenols

U2 - 10.1016/j.jff.2022.105246

DO - 10.1016/j.jff.2022.105246

M3 - Article

AN - SCOPUS:85138775605

SN - 1756-4646

VL - 97

JO - Journal of Functional Foods

JF - Journal of Functional Foods

M1 - 105246

ER -

Clinical Investigation of French Maritime Pine Bark Extract on Attention-Deficit Hyperactivity Disorder as compared to Methylphenidate and Placebo: Part 1: Efficacy in a Randomised Trial

Abstract

Keywords

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