TY - JOUR
T1 - Clinical and Pathological Findings in SARS-CoV-2 Disease Outbreaks in Farmed Mink (Neovison vison)
AU - Molenaar, Robert Jan
AU - Vreman, Sandra
AU - Hakze-van der Honing, Renate W.
AU - Zwart, Rob
AU - de Rond, Jan
AU - Weesendorp, Eefke
AU - Smit, Lidwien A.M.
AU - Koopmans, Marion
AU - Bouwstra, Ruth
AU - Stegeman, Arjan
AU - van der Poel, Wim H.M.
PY - 2020/9
Y1 - 2020/9
N2 - SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.
AB - SARS-CoV-2, the causative agent of COVID-19, caused respiratory disease outbreaks with increased mortality in 4 mink farms in the Netherlands. The most striking postmortem finding was an acute interstitial pneumonia, which was found in nearly all examined mink that died at the peak of the outbreaks. Acute alveolar damage was a consistent histopathological finding in mink that died with pneumonia. SARS-CoV-2 infections were confirmed by detection of viral RNA in throat swabs and by immunohistochemical detection of viral antigen in nasal conchae, trachea, and lung. Clinically, the outbreaks lasted for about 4 weeks but some animals were still polymerase chain reaction–positive for SARS-CoV-2 in throat swabs after clinical signs had disappeared. This is the first report of the clinical and pathological characteristics of SARS-CoV-2 outbreaks in mink farms.
KW - COVID-19
KW - mink
KW - pneumonia
KW - respiratory disease
KW - severe acute respiratory syndrome coronavirus 2
KW - zoonoses
UR - https://doi.org/10.25384/SAGE.c.5060856
U2 - 10.1177/0300985820943535
DO - 10.1177/0300985820943535
M3 - Article
AN - SCOPUS:85087937563
SN - 0300-9858
VL - 57
SP - 653
EP - 657
JO - Veterinary Pathology
JF - Veterinary Pathology
IS - 5
ER -