Classification of temporal profiles of F4+ E. coli shedding and faecal dry matter in experimental post-weaning diarrhoea of pigs

P.L. Geenen, J. van der Meulen, A. Bouma, B. Engel, J.A.P. Heesterbeek, M.C.M. de Jong

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Scopus)

Abstract

Enterotoxigenic F4+ Escherichia coli can colonize the intestine of pigs and cause diarrhoea. Our primary goal was to find a discriminant rule to discriminate between F4+ E. coli shedding profiles as this may reflect differences in the infectiousness of pigs. Our secondary goal was to find a discriminant rule to discriminate between diarrhoeic and non-diarrhoeic pigs. Repeated measurements (bacterial shedding and percentage dry matter of faeces) were taken of 74 weaned pigs that were infected experimentally with F4+ E. coli. These measurements were summarized into two new variables by means of a principal components analysis. Discriminant rules were derived based on these summary variables by fitting a mixture of normal distributions. Finally, the association between the classifications (as derived from the discriminant rules) and the occurrence in the pigs of the F4 receptor, an adhesion site for F4+ E. coli, was studied. We found that only the classification based on bacterial shedding allowed us to distinguish two significantly different groups of pigs (high and low shedders). Presence of the F4 receptor was associated strongly with pigs being high shedders.
Original languageEnglish
Pages (from-to)1001-1009
JournalEpidemiology and Infection
Volume135
Issue number6
DOIs
Publication statusPublished - 2007

Fingerprint

Weaning
Diarrhea
Swine
Escherichia coli
Bacterial Shedding
Enterotoxigenic Escherichia coli
Normal Distribution
Principal Component Analysis
Feces
Intestines

Keywords

  • enterotoxigenic escherichia-coli
  • postweaning diarrhea
  • weaned pigs
  • experimental-model
  • small-intestine
  • brush-borders
  • k88
  • phenotypes
  • piglets
  • colibacillosis

Cite this

@article{c3d01a8f5f784f63bdae08c6fd0c6e31,
title = "Classification of temporal profiles of F4+ E. coli shedding and faecal dry matter in experimental post-weaning diarrhoea of pigs",
abstract = "Enterotoxigenic F4+ Escherichia coli can colonize the intestine of pigs and cause diarrhoea. Our primary goal was to find a discriminant rule to discriminate between F4+ E. coli shedding profiles as this may reflect differences in the infectiousness of pigs. Our secondary goal was to find a discriminant rule to discriminate between diarrhoeic and non-diarrhoeic pigs. Repeated measurements (bacterial shedding and percentage dry matter of faeces) were taken of 74 weaned pigs that were infected experimentally with F4+ E. coli. These measurements were summarized into two new variables by means of a principal components analysis. Discriminant rules were derived based on these summary variables by fitting a mixture of normal distributions. Finally, the association between the classifications (as derived from the discriminant rules) and the occurrence in the pigs of the F4 receptor, an adhesion site for F4+ E. coli, was studied. We found that only the classification based on bacterial shedding allowed us to distinguish two significantly different groups of pigs (high and low shedders). Presence of the F4 receptor was associated strongly with pigs being high shedders.",
keywords = "enterotoxigenic escherichia-coli, postweaning diarrhea, weaned pigs, experimental-model, small-intestine, brush-borders, k88, phenotypes, piglets, colibacillosis",
author = "P.L. Geenen and {van der Meulen}, J. and A. Bouma and B. Engel and J.A.P. Heesterbeek and {de Jong}, M.C.M.",
year = "2007",
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Classification of temporal profiles of F4+ E. coli shedding and faecal dry matter in experimental post-weaning diarrhoea of pigs. / Geenen, P.L.; van der Meulen, J.; Bouma, A.; Engel, B.; Heesterbeek, J.A.P.; de Jong, M.C.M.

In: Epidemiology and Infection, Vol. 135, No. 6, 2007, p. 1001-1009.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Classification of temporal profiles of F4+ E. coli shedding and faecal dry matter in experimental post-weaning diarrhoea of pigs

AU - Geenen, P.L.

AU - van der Meulen, J.

AU - Bouma, A.

AU - Engel, B.

AU - Heesterbeek, J.A.P.

AU - de Jong, M.C.M.

PY - 2007

Y1 - 2007

N2 - Enterotoxigenic F4+ Escherichia coli can colonize the intestine of pigs and cause diarrhoea. Our primary goal was to find a discriminant rule to discriminate between F4+ E. coli shedding profiles as this may reflect differences in the infectiousness of pigs. Our secondary goal was to find a discriminant rule to discriminate between diarrhoeic and non-diarrhoeic pigs. Repeated measurements (bacterial shedding and percentage dry matter of faeces) were taken of 74 weaned pigs that were infected experimentally with F4+ E. coli. These measurements were summarized into two new variables by means of a principal components analysis. Discriminant rules were derived based on these summary variables by fitting a mixture of normal distributions. Finally, the association between the classifications (as derived from the discriminant rules) and the occurrence in the pigs of the F4 receptor, an adhesion site for F4+ E. coli, was studied. We found that only the classification based on bacterial shedding allowed us to distinguish two significantly different groups of pigs (high and low shedders). Presence of the F4 receptor was associated strongly with pigs being high shedders.

AB - Enterotoxigenic F4+ Escherichia coli can colonize the intestine of pigs and cause diarrhoea. Our primary goal was to find a discriminant rule to discriminate between F4+ E. coli shedding profiles as this may reflect differences in the infectiousness of pigs. Our secondary goal was to find a discriminant rule to discriminate between diarrhoeic and non-diarrhoeic pigs. Repeated measurements (bacterial shedding and percentage dry matter of faeces) were taken of 74 weaned pigs that were infected experimentally with F4+ E. coli. These measurements were summarized into two new variables by means of a principal components analysis. Discriminant rules were derived based on these summary variables by fitting a mixture of normal distributions. Finally, the association between the classifications (as derived from the discriminant rules) and the occurrence in the pigs of the F4 receptor, an adhesion site for F4+ E. coli, was studied. We found that only the classification based on bacterial shedding allowed us to distinguish two significantly different groups of pigs (high and low shedders). Presence of the F4 receptor was associated strongly with pigs being high shedders.

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KW - postweaning diarrhea

KW - weaned pigs

KW - experimental-model

KW - small-intestine

KW - brush-borders

KW - k88

KW - phenotypes

KW - piglets

KW - colibacillosis

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SN - 0950-2688

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