Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance

H.C.E. Rooney, J.W. van t Klooster, R.A.L. van der Hoorn, M.H.A.J. Joosten, J.D.G. Jones, P.J.G.M. de Wit

Research output: Contribution to journalArticleAcademicpeer-review

300 Citations (Scopus)

Abstract

How plants recognize pathogens and activate defense is still mysterious. Direct interaction between pathogen avirulence (Avr) proteins and plant disease resistance proteins is the exception rather than the rule. During infection, Cladosporium fulvum secretes Avr2 protein into the apoplast of tomato leaves and, in the presence of the extracellular leucine-rich repeat receptor-like Cf-2 protein, triggers a hypersensitive response (HR) that also requires the extracellular tomato cysteine protease Rcr3. We show here that Avr2 binds and inhibits Rcr3 and propose that the Rcr3-Avr2 complex enables the Cf-2 protein to activate an HR
Original languageEnglish
Pages (from-to)1783-1786
JournalScience
Volume308
Issue number5729
DOIs
Publication statusPublished - 2005

Keywords

  • for-gene concept
  • iii effector
  • cysteine protease
  • avirulence gene
  • proteins
  • fulvum
  • arabidopsis
  • plants
  • rin4
  • avrrpt2

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