Citrate increases glass transition temperature of vitrified sucrose preparations

E.P.W. Kets, P.J. Lipelaar, F.A. Hoekstra, H. Vromans

Research output: Contribution to journalArticleAcademicpeer-review

45 Citations (Scopus)


The aim of this study was to investigate the effect of sodium citrate on the properties of dried amorphous sucrose glasses. Addition of sodium citrate to a sucrose solution followed by freeze-drying or convective drying resulted in a glass transition temperature (T-g) that was higher than the well-studied sucrose T-g. This result was obtained either at reduced water content of the analysed sample or by removal of water during Modulated DSC analysis. After removal of the remaining water (
Original languageEnglish
Pages (from-to)46-54
Issue number1
Publication statusPublished - 2004


  • citric-acid
  • lyophilization
  • anhydrobiosis
  • vitrification
  • prokaryotes
  • complexes
  • protein
  • borate
  • state


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