Abstract
Background: Odd-chain fatty acids (OCFA) pentadecanoic (15:0) and heptadecanoic acid (17:0) are considered to reflect dairy intakes in studies on cardiometabolic outcomes. A recent randomized controlled trial on dietary fiber showed that circulating proportions of these OCFA may also be related to fiber intake, which may result from fermentation by gut microbes.
Objective: To examine the associations between circulating OCFA and dairy and fiber intake in patients with a history of myocardial infarction.
Methods: We performed cross-sectional analyses in a subsample of 896 Dutch post-MI patients of the Alpha Omega Cohort. Proportions of OCFA (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesterol esters (CE). Dietary intakes (g/d) were assessed using a 203-item validated food frequency questionnaire. Spearman correlations (r) were computed between circulating OCFA in PL and CE and intakes of total dairy, types of dairy products, dietary fiber and total meat.
Results: Patients were on average 69 years old, 78% was male and 89% used statins. Dairy intake was predominantly from milk and yogurt. PL 15:0 was positively correlated with total dairy intake (r=0.16, p<0.001; Table 1), especially yogurt. PL 15:0 was not correlated with dietary fiber (r=0.01, p=0.75). For CE 15:0, correlations were similar. PL 17:0 was positively correlated with total dairy (r=0.15, p<0.001), but also with dietary fiber (r=0.13, p<0.001). For CE 17:0 similar correlations were observed, although somewhat weaker (dairy: r=0.10, p=0.003; fiber: r=0.09, p=0.009). OCFA were not significantly correlated with meat intake.
Conclusions: Plasma PL 15:0 and CE 15:0 were related to dairy and not to fiber intake. PL 17:0 and CE 17:0 were equally related to dairy and fiber intake. Cardiometabolic health benefits attributed to biomarkers of dairy intake, especially 17:0, may be (partly) attributable to fiber intake. Further research is needed into endogenous OCFA synthesis as a result of fermentation of dietary fiber by gut microbes.
Objective: To examine the associations between circulating OCFA and dairy and fiber intake in patients with a history of myocardial infarction.
Methods: We performed cross-sectional analyses in a subsample of 896 Dutch post-MI patients of the Alpha Omega Cohort. Proportions of OCFA (as % of total fatty acids) were measured in plasma phospholipids (PL) and cholesterol esters (CE). Dietary intakes (g/d) were assessed using a 203-item validated food frequency questionnaire. Spearman correlations (r) were computed between circulating OCFA in PL and CE and intakes of total dairy, types of dairy products, dietary fiber and total meat.
Results: Patients were on average 69 years old, 78% was male and 89% used statins. Dairy intake was predominantly from milk and yogurt. PL 15:0 was positively correlated with total dairy intake (r=0.16, p<0.001; Table 1), especially yogurt. PL 15:0 was not correlated with dietary fiber (r=0.01, p=0.75). For CE 15:0, correlations were similar. PL 17:0 was positively correlated with total dairy (r=0.15, p<0.001), but also with dietary fiber (r=0.13, p<0.001). For CE 17:0 similar correlations were observed, although somewhat weaker (dairy: r=0.10, p=0.003; fiber: r=0.09, p=0.009). OCFA were not significantly correlated with meat intake.
Conclusions: Plasma PL 15:0 and CE 15:0 were related to dairy and not to fiber intake. PL 17:0 and CE 17:0 were equally related to dairy and fiber intake. Cardiometabolic health benefits attributed to biomarkers of dairy intake, especially 17:0, may be (partly) attributable to fiber intake. Further research is needed into endogenous OCFA synthesis as a result of fermentation of dietary fiber by gut microbes.
| Original language | English |
|---|---|
| Article number | P034 |
| Journal | Circulation |
| Volume | 139 |
| Issue number | Suppl_1 |
| DOIs | |
| Publication status | Published - 5 Mar 2019 |