Circulating n-3 fatty acids and linoleic acid as indicators of dietary fatty acid intake in post-myocardial infarction patients

K. Pertiwi*, D.E. Kok, A.J. Wanders, J. de Goede, P.L. Zock, J.M. Geleijnse

*Corresponding author for this work

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1 Citation (Scopus)

Abstract

Background and aims: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. Methods and results: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated. Circulating individual FA (% total FA) were assessed in cholesteryl esters (CE; n = 4066), phospholipids (PL; n = 838), and additionally in total plasma for DHA and LA (n = 739). Spearman correlation coefficients (rs) were calculated for dietary vs. circulating FA. Circulating FA were also compared across dietary FA quintiles, overall and in subgroups by sex, obesity, diabetes, statin use, and high alcohol intake. Patients were on average 69 years old and 79% was male. Moderate correlations between dietary and circulating levels were observed for EPA (rs ∼0.4 in CE and PL) and DHA (rs ∼0.5 in CE and PL, ∼0.4 in total plasma), but not for ALA (rs ∼0.0). Weak correlations were observed for LA (rs 0.1 to 0.2). Plasma LA was significantly lower in statin users and in patients with a high alcohol intake. Conclusions: In post-MI patients, dietary EPA and DHA were well reflected in circulating levels. This was not the case for LA, which may partly be influenced by alcohol use and statins.

Original languageEnglish
Pages (from-to)343-350
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume29
Issue number4
DOIs
Publication statusPublished - Apr 2019

Fingerprint

Omega-3 Fatty Acids
Linoleic Acid
Fatty Acids
Myocardial Infarction
Docosahexaenoic Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Eicosapentaenoic Acid
alpha-Linolenic Acid
Alcohols
Cholesterol Esters
Phospholipids
Obesity
Lipids
Food
Population

Keywords

  • Biomarkers
  • Cardiac patients
  • Circulating fatty acids
  • Dietary fatty acids
  • Food frequency questionnaire
  • Linoleic acid
  • n-3 fatty acids
  • Plasma fatty acids

Cite this

@article{8294d32fbca14006bb0e2f8415309adf,
title = "Circulating n-3 fatty acids and linoleic acid as indicators of dietary fatty acid intake in post-myocardial infarction patients",
abstract = "Background and aims: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. Methods and results: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated. Circulating individual FA ({\%} total FA) were assessed in cholesteryl esters (CE; n = 4066), phospholipids (PL; n = 838), and additionally in total plasma for DHA and LA (n = 739). Spearman correlation coefficients (rs) were calculated for dietary vs. circulating FA. Circulating FA were also compared across dietary FA quintiles, overall and in subgroups by sex, obesity, diabetes, statin use, and high alcohol intake. Patients were on average 69 years old and 79{\%} was male. Moderate correlations between dietary and circulating levels were observed for EPA (rs ∼0.4 in CE and PL) and DHA (rs ∼0.5 in CE and PL, ∼0.4 in total plasma), but not for ALA (rs ∼0.0). Weak correlations were observed for LA (rs 0.1 to 0.2). Plasma LA was significantly lower in statin users and in patients with a high alcohol intake. Conclusions: In post-MI patients, dietary EPA and DHA were well reflected in circulating levels. This was not the case for LA, which may partly be influenced by alcohol use and statins.",
keywords = "Biomarkers, Cardiac patients, Circulating fatty acids, Dietary fatty acids, Food frequency questionnaire, Linoleic acid, n-3 fatty acids, Plasma fatty acids",
author = "K. Pertiwi and D.E. Kok and A.J. Wanders and {de Goede}, J. and P.L. Zock and J.M. Geleijnse",
year = "2019",
month = "4",
doi = "10.1016/j.numecd.2018.12.010",
language = "English",
volume = "29",
pages = "343--350",
journal = "Nutrition, Metabolism & Cardiovascular Diseases",
issn = "0939-4753",
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}

Circulating n-3 fatty acids and linoleic acid as indicators of dietary fatty acid intake in post-myocardial infarction patients. / Pertiwi, K.; Kok, D.E.; Wanders, A.J.; de Goede, J.; Zock, P.L.; Geleijnse, J.M.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 29, No. 4, 04.2019, p. 343-350.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Circulating n-3 fatty acids and linoleic acid as indicators of dietary fatty acid intake in post-myocardial infarction patients

AU - Pertiwi, K.

AU - Kok, D.E.

AU - Wanders, A.J.

AU - de Goede, J.

AU - Zock, P.L.

AU - Geleijnse, J.M.

PY - 2019/4

Y1 - 2019/4

N2 - Background and aims: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. Methods and results: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated. Circulating individual FA (% total FA) were assessed in cholesteryl esters (CE; n = 4066), phospholipids (PL; n = 838), and additionally in total plasma for DHA and LA (n = 739). Spearman correlation coefficients (rs) were calculated for dietary vs. circulating FA. Circulating FA were also compared across dietary FA quintiles, overall and in subgroups by sex, obesity, diabetes, statin use, and high alcohol intake. Patients were on average 69 years old and 79% was male. Moderate correlations between dietary and circulating levels were observed for EPA (rs ∼0.4 in CE and PL) and DHA (rs ∼0.5 in CE and PL, ∼0.4 in total plasma), but not for ALA (rs ∼0.0). Weak correlations were observed for LA (rs 0.1 to 0.2). Plasma LA was significantly lower in statin users and in patients with a high alcohol intake. Conclusions: In post-MI patients, dietary EPA and DHA were well reflected in circulating levels. This was not the case for LA, which may partly be influenced by alcohol use and statins.

AB - Background and aims: Population-based studies often use plasma fatty acids (FAs) as objective indicators of FA intake, especially for n-3 FA and linoleic acid (LA). The relation between dietary and circulating FA in cardiometabolic patients is largely unknown. We examined whether dietary n-3 FA and LA were reflected in plasma lipid pools in post-myocardial infarction (MI) patients. Methods and results: Patients in Alpha Omega Cohort filled out a 203-item food-frequency questionnaire from which eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), and LA intake were calculated. Circulating individual FA (% total FA) were assessed in cholesteryl esters (CE; n = 4066), phospholipids (PL; n = 838), and additionally in total plasma for DHA and LA (n = 739). Spearman correlation coefficients (rs) were calculated for dietary vs. circulating FA. Circulating FA were also compared across dietary FA quintiles, overall and in subgroups by sex, obesity, diabetes, statin use, and high alcohol intake. Patients were on average 69 years old and 79% was male. Moderate correlations between dietary and circulating levels were observed for EPA (rs ∼0.4 in CE and PL) and DHA (rs ∼0.5 in CE and PL, ∼0.4 in total plasma), but not for ALA (rs ∼0.0). Weak correlations were observed for LA (rs 0.1 to 0.2). Plasma LA was significantly lower in statin users and in patients with a high alcohol intake. Conclusions: In post-MI patients, dietary EPA and DHA were well reflected in circulating levels. This was not the case for LA, which may partly be influenced by alcohol use and statins.

KW - Biomarkers

KW - Cardiac patients

KW - Circulating fatty acids

KW - Dietary fatty acids

KW - Food frequency questionnaire

KW - Linoleic acid

KW - n-3 fatty acids

KW - Plasma fatty acids

U2 - 10.1016/j.numecd.2018.12.010

DO - 10.1016/j.numecd.2018.12.010

M3 - Article

VL - 29

SP - 343

EP - 350

JO - Nutrition, Metabolism & Cardiovascular Diseases

JF - Nutrition, Metabolism & Cardiovascular Diseases

SN - 0939-4753

IS - 4

ER -