Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

Fränzel J.B. van Duijnhoven*, Mazda Jenab, Kristian Hveem, Peter D. Siersema, Veronika Fedirko, Eric J. Duell, Ellen Kampman, Anouk Halfweeg, Henk J. van Kranen, Jody M.W. van den Ouweland, Elisabete Weiderpass, Neil Murphy, Arnulf Langhammer, Eivind Ness-Jensen, Anja Olsen, Anne Tjønneland, Kim Overvad, Claire Cadeau, Marina Kvaskoff, Marie Christine Boutron-RuaultVerena A. Katzke, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anastasia Kotanidou, Maria Kritikou, Domenico Palli, Claudia Agnoli, Rosario Tumino, Salvatore Panico, Giuseppe Matullo, Petra Peeters, Magritt Brustad, Karina Standahl Olsen, Cristina Lasheras, Mireia Obón-Santacana, María José Sánchez, Miren Dorronsoro, Maria Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Martin Almquist, Frida Renström, Weimin Ye, Nick Wareham, Kay Tee Khaw, Kathryn E. Bradbury, Heinz Freisling, Dagfinn Aune, Teresa Norat, Elio Riboli, H.B. Bueno-de-Mesquita

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Scopus)

Abstract

Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Original languageEnglish
Pages (from-to)1189-1201
JournalInternational Journal of Cancer
Volume142
Issue number6
Early online date22 Nov 2017
DOIs
Publication statusPublished - 15 Mar 2018

Keywords

  • Cancer epidemiology
  • Nested case-control study
  • Pancreatic cancer
  • Vitamin D

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    van Duijnhoven, F. J. B., Jenab, M., Hveem, K., Siersema, P. D., Fedirko, V., Duell, E. J., Kampman, E., Halfweeg, A., van Kranen, H. J., van den Ouweland, J. M. W., Weiderpass, E., Murphy, N., Langhammer, A., Ness-Jensen, E., Olsen, A., Tjønneland, A., Overvad, K., Cadeau, C., Kvaskoff, M., ... Bueno-de-Mesquita, H. B. (2018). Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations. International Journal of Cancer, 142(6), 1189-1201. https://doi.org/10.1002/ijc.31146